Coronary stent failure in patients with diabetes: A nationwide observational study from SWEDEHEART
<p dir="ltr">Objective: The association between diabetes and coronary stent failure is poorly established with second-generation drug-eluting stents (DES). We aimed to evaluate the risk of stent failure in patients with diabetes compared to subjects without diabetes after implantatio...
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2025
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| _version_ | 1849927630483095552 |
|---|---|
| author | Irene Santos-Pardo (17607279) |
| author2 | Robin Hofmann (10304126) Mikael Andersson Franko (15277840) Thomas Nyström (2838080) |
| author2_role | author author author |
| author_facet | Irene Santos-Pardo (17607279) Robin Hofmann (10304126) Mikael Andersson Franko (15277840) Thomas Nyström (2838080) |
| author_role | author |
| dc.creator.none.fl_str_mv | Irene Santos-Pardo (17607279) Robin Hofmann (10304126) Mikael Andersson Franko (15277840) Thomas Nyström (2838080) |
| dc.date.none.fl_str_mv | 2025-11-25T14:42:43Z |
| dc.identifier.none.fl_str_mv | 10.2337/figshare.30500951.v1 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Coronary_stent_failure_in_patients_with_diabetes_A_nationwide_observational_study_from_SWEDEHEART/30500951 |
| dc.rights.none.fl_str_mv | CC BY-NC-SA 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Other health sciences not elsewhere classified Type 1 Diabetes Type 2 Diabetes Drug Eluting Stent Restenosis Thrombosis |
| dc.title.none.fl_str_mv | Coronary stent failure in patients with diabetes: A nationwide observational study from SWEDEHEART |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p dir="ltr">Objective: The association between diabetes and coronary stent failure is poorly established with second-generation drug-eluting stents (DES). We aimed to evaluate the risk of stent failure in patients with diabetes compared to subjects without diabetes after implantation of second-generation DES.</p><p dir="ltr">Research design and Methods: All patients in Sweden who received second-generation DES between 2010 and 2020 were included and categorized into three groups: type 1, type 2 diabetes, and subjects without diabetes (reference group). The primary endpoint was stent failure, defined as in-stent restenosis or stent thrombosis. Adjusted hazard ratios (HR) with 95% confidence intervals (CI) were estimated by Cox regression models. Sensitivity analyses were performed to address missing data in covariates and account for death as a competing risk.</p><p dir="ltr">Results: The study included 160,523 patients: 2,406 with type 1, 43,377 with type 2 diabetes and 114,740 without diabetes. Seventy-one percent were male. Over a mean follow-up of 4.5 years, 5,510 stent failure events occurred. The fully adjusted HR for stent failure was 2.28 (95% CI 1.97–2.65) for type 1 and 1.35 (95% CI 1.27–1.44) for type 2 diabetes, compared to subjects without diabetes. Sensitivity analyses confirmed the robustness of the findings, with both in-stent restenosis and stent thrombosis contributing to the increased risk. </p><p dir="ltr">Conclusion: We observed a significantly higher risk of second-generation DES stent failure in individuals with type 1 diabetes followed by those with type 2 diabetes, compared to subjects without diabetes. This elevated risk was attributed to both in-stent restenosis and stent thrombosis. </p> |
| eu_rights_str_mv | openAccess |
| id | Manara_28e948a26e46d281bf800758d1d8e78b |
| identifier_str_mv | 10.2337/figshare.30500951.v1 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30500951 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY-NC-SA 4.0 |
| spelling | Coronary stent failure in patients with diabetes: A nationwide observational study from SWEDEHEARTIrene Santos-Pardo (17607279)Robin Hofmann (10304126)Mikael Andersson Franko (15277840)Thomas Nyström (2838080)Other health sciences not elsewhere classifiedType 1 DiabetesType 2 DiabetesDrug Eluting StentRestenosisThrombosis<p dir="ltr">Objective: The association between diabetes and coronary stent failure is poorly established with second-generation drug-eluting stents (DES). We aimed to evaluate the risk of stent failure in patients with diabetes compared to subjects without diabetes after implantation of second-generation DES.</p><p dir="ltr">Research design and Methods: All patients in Sweden who received second-generation DES between 2010 and 2020 were included and categorized into three groups: type 1, type 2 diabetes, and subjects without diabetes (reference group). The primary endpoint was stent failure, defined as in-stent restenosis or stent thrombosis. Adjusted hazard ratios (HR) with 95% confidence intervals (CI) were estimated by Cox regression models. Sensitivity analyses were performed to address missing data in covariates and account for death as a competing risk.</p><p dir="ltr">Results: The study included 160,523 patients: 2,406 with type 1, 43,377 with type 2 diabetes and 114,740 without diabetes. Seventy-one percent were male. Over a mean follow-up of 4.5 years, 5,510 stent failure events occurred. The fully adjusted HR for stent failure was 2.28 (95% CI 1.97–2.65) for type 1 and 1.35 (95% CI 1.27–1.44) for type 2 diabetes, compared to subjects without diabetes. Sensitivity analyses confirmed the robustness of the findings, with both in-stent restenosis and stent thrombosis contributing to the increased risk. </p><p dir="ltr">Conclusion: We observed a significantly higher risk of second-generation DES stent failure in individuals with type 1 diabetes followed by those with type 2 diabetes, compared to subjects without diabetes. This elevated risk was attributed to both in-stent restenosis and stent thrombosis. </p>2025-11-25T14:42:43ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.2337/figshare.30500951.v1https://figshare.com/articles/figure/Coronary_stent_failure_in_patients_with_diabetes_A_nationwide_observational_study_from_SWEDEHEART/30500951CC BY-NC-SA 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/305009512025-11-25T14:42:43Z |
| spellingShingle | Coronary stent failure in patients with diabetes: A nationwide observational study from SWEDEHEART Irene Santos-Pardo (17607279) Other health sciences not elsewhere classified Type 1 Diabetes Type 2 Diabetes Drug Eluting Stent Restenosis Thrombosis |
| status_str | publishedVersion |
| title | Coronary stent failure in patients with diabetes: A nationwide observational study from SWEDEHEART |
| title_full | Coronary stent failure in patients with diabetes: A nationwide observational study from SWEDEHEART |
| title_fullStr | Coronary stent failure in patients with diabetes: A nationwide observational study from SWEDEHEART |
| title_full_unstemmed | Coronary stent failure in patients with diabetes: A nationwide observational study from SWEDEHEART |
| title_short | Coronary stent failure in patients with diabetes: A nationwide observational study from SWEDEHEART |
| title_sort | Coronary stent failure in patients with diabetes: A nationwide observational study from SWEDEHEART |
| topic | Other health sciences not elsewhere classified Type 1 Diabetes Type 2 Diabetes Drug Eluting Stent Restenosis Thrombosis |