DBLα-tag sequencing in clinical and asymptomatic infections after short term culture.

DBLα-tag sequencing in clinical and asymptomatic infections after short term culture.

<p>Comparison of DBLα-tags in 16 wet season asymptomatic (midWet) samples (left) and 20 MAL (right) ex vivo samples (0h) and the corresponding short-term culture timepoints (12h). Individual clusters are plotted on the y-axis with lines connecting clusters detected at the 0h and 12h timepoint....

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Main Author: Sukai Ceesay (3472853) (author)
Other Authors: Martin Kampmann (5688443) (author), Lasse Votborg-Novél (20138013) (author), Helle Smedegaard Hansson (21519864) (author), Rasmus Weisel Jensen (15216781) (author), Manuela Carrasquilla (2897933) (author), Hamidou Cisse (21519867) (author), Louise Turner (55117) (author), Usama Dabbas (21519870) (author), Christina Ntalla (20138016) (author), Silke Bandermann (3611189) (author), Safiatou Doumbo (248618) (author), Didier Doumtabe (248621) (author), Aissata Ongoiba (248615) (author), Kassoum Kayentao (248612) (author), Boubacar Traore (248609) (author), Peter D. Crompton (9462929) (author), Thomas Lavstsen (75520) (author), Silvia Portugal (3385946) (author)
Published: 2025
Subjects:
Microbiology
Genetics
Immunology
Infectious Diseases
Computational Biology
Biological Sciences not elsewhere classified
Physical Sciences not elsewhere classified
used bioinformatic tools
upstream sequence type
main determinant limiting
achieved remains unknown
severe malaria cases
malaria cases compared
term infections may
seasonal transmission areas
clinical malaria occurs
clinical malaria cases
div >< p
plasmodium falciparum </
month dry season
binding pfemp1 dominated
asymptomatic carriers expressed
malaria transmission
clinical cases
asymptomatic carriers
falciparum </
subclinical infections
clinical presentation
wet season
dry season
binding phenotype
binding pfemp1
vars </
var </
wet seasons
transcripts attributed
transcript variation
transcript levels
sustain long
significant difference
shows circulation
sequenced expressed
reduced cytoadhesion
prolonged circulation
parasite ’
malian children
lower proportions
lower levels
larger proportion
infected erythrocytes
immune selection
host ’
host immunity
higher titers
gene expression
expresses fewer
domain composition
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Summary:<p>Comparison of DBLα-tags in 16 wet season asymptomatic (midWet) samples (left) and 20 MAL (right) ex vivo samples (0h) and the corresponding short-term culture timepoints (12h). Individual clusters are plotted on the y-axis with lines connecting clusters detected at the 0h and 12h timepoint. Dot size indicates proportion of reads in sample mapping to the cluster. DBLα-tags were annotated with DBLα subtype by best BLAST hit in a database of annotated <i>var</i> genes.</p> <p>(TIF)</p>

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