Many more differentially expressed genes (DEGs) result from VOR treatment and Vpr expression than either condition alone.

A) Primary CD4+ T cells from 3 seronegative donors were infected with either HIV-GFP or HIV-GFP-Vpr and treated with 500nM vorinostat starting 2 days post-infection (dpi). At 14dpi, cells were analyzed by flow cytometry, and RNA was isolated for bul...

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主要作者:	Catherine A. Lewis (22177707) (author)
其他作者:	David M. Margolis (244046) (author), Edward P. Browne (8913893) (author)
出版:	2025
主题:	Cell Biology Molecular Biology Biotechnology Immunology Developmental Biology Cancer Infectious Diseases Virology vorinostat potently enhances viral factors shape viral factors interact sup >+</ sup specific viral factors div >< p critical cellular factors 1 reporter strains 1 accessory proteins 1 accessory protein reservoir formation selects preventing reservoir formation regulate latency establishment 1 latency results 1 latency establishment prevents hiv transmission cure hiv infection vpr &# 8217 latent viral reservoir 1 protein vpr whether hdacs interact cell latency model host cell factors promoting hiv expression central memory cd4 latent reservoir central memory 1 entry vpr expression new latency cell subtypes cell death latent proviruses single hiv individual hiv allow hiv vpr possesses vpr plays significant increase recently shown promoting activity primary cd4 mediated restriction induced apoptosis histone deacetylases findings suggest dramatically improved clinical prognosis binding domain antiretroviral therapy
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Many more differentially expressed genes (DEGs) result from VOR treatment and Vpr expression than either condition alone.

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