Pathway and functional analysis of the hub gene.
<p><b>(A)</b> The top five pathways positively associated with <i>BMX</i>. <b>(B)</b> The top five pathways negatively associated with <i>BMX</i>.</p>
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2025
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| _version_ | 1852018462570840064 |
|---|---|
| author | Tianbao Feng (21722233) |
| author2 | Jiating Hu (10502876) Mi Xie (2065444) Guodong Shi (314927) Qi Wang (22418) Jingyuan Yao (15188771) Xiaoqin Liu (296429) |
| author2_role | author author author author author author |
| author_facet | Tianbao Feng (21722233) Jiating Hu (10502876) Mi Xie (2065444) Guodong Shi (314927) Qi Wang (22418) Jingyuan Yao (15188771) Xiaoqin Liu (296429) |
| author_role | author |
| dc.creator.none.fl_str_mv | Tianbao Feng (21722233) Jiating Hu (10502876) Mi Xie (2065444) Guodong Shi (314927) Qi Wang (22418) Jingyuan Yao (15188771) Xiaoqin Liu (296429) |
| dc.date.none.fl_str_mv | 2025-07-15T17:39:11Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0328002.g009 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Pathway_and_functional_analysis_of_the_hub_gene_/29576848 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biochemistry Cell Biology Genetics Molecular Biology Immunology Biological Sciences not elsewhere classified spinal cord injury severely impacts motor programmed cell death div >< p debilitating neurological condition promising diagnostic potential potential therapeutic target 707 upregulated genes functional enrichment analysis gene expression omnibus panoptosis scores calculation identify hub genes consistently identified across panoptosis gene sets gene gsea analysis hub genes related gene potential drugs related genes elevated expression targeting panoptosis panoptosis score 23 panoptosis time pcr study seeks significantly higher significant roles significant challenges results underscore rat model quantitative real performed single patient quality pathways associated intersected degs inflammatory response immune response ihc ). healthy controls hc samples future studies experimentally confirm experimental validation emerging concept datasets gse151371 casp5 </ biological functions autonomic functions auc value |
| dc.title.none.fl_str_mv | Pathway and functional analysis of the hub gene. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p><b>(A)</b> The top five pathways positively associated with <i>BMX</i>. <b>(B)</b> The top five pathways negatively associated with <i>BMX</i>.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_2c5e8f4cd3bc83c904f998f69ffb4269 |
| identifier_str_mv | 10.1371/journal.pone.0328002.g009 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/29576848 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Pathway and functional analysis of the hub gene.Tianbao Feng (21722233)Jiating Hu (10502876)Mi Xie (2065444)Guodong Shi (314927)Qi Wang (22418)Jingyuan Yao (15188771)Xiaoqin Liu (296429)BiochemistryCell BiologyGeneticsMolecular BiologyImmunologyBiological Sciences not elsewhere classifiedspinal cord injuryseverely impacts motorprogrammed cell deathdiv >< pdebilitating neurological conditionpromising diagnostic potentialpotential therapeutic target707 upregulated genesfunctional enrichment analysisgene expression omnibuspanoptosis scores calculationidentify hub genesconsistently identified acrosspanoptosis gene setsgene gsea analysishub genesrelated genepotential drugsrelated geneselevated expressiontargeting panoptosispanoptosis score23 panoptosistime pcrstudy seekssignificantly highersignificant rolessignificant challengesresults underscorerat modelquantitative realperformed singlepatient qualitypathways associatedintersected degsinflammatory responseimmune responseihc ).healthy controlshc samplesfuture studiesexperimentally confirmexperimental validationemerging conceptdatasets gse151371casp5 </biological functionsautonomic functionsauc value<p><b>(A)</b> The top five pathways positively associated with <i>BMX</i>. <b>(B)</b> The top five pathways negatively associated with <i>BMX</i>.</p>2025-07-15T17:39:11ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pone.0328002.g009https://figshare.com/articles/figure/Pathway_and_functional_analysis_of_the_hub_gene_/29576848CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/295768482025-07-15T17:39:11Z |
| spellingShingle | Pathway and functional analysis of the hub gene. Tianbao Feng (21722233) Biochemistry Cell Biology Genetics Molecular Biology Immunology Biological Sciences not elsewhere classified spinal cord injury severely impacts motor programmed cell death div >< p debilitating neurological condition promising diagnostic potential potential therapeutic target 707 upregulated genes functional enrichment analysis gene expression omnibus panoptosis scores calculation identify hub genes consistently identified across panoptosis gene sets gene gsea analysis hub genes related gene potential drugs related genes elevated expression targeting panoptosis panoptosis score 23 panoptosis time pcr study seeks significantly higher significant roles significant challenges results underscore rat model quantitative real performed single patient quality pathways associated intersected degs inflammatory response immune response ihc ). healthy controls hc samples future studies experimentally confirm experimental validation emerging concept datasets gse151371 casp5 </ biological functions autonomic functions auc value |
| status_str | publishedVersion |
| title | Pathway and functional analysis of the hub gene. |
| title_full | Pathway and functional analysis of the hub gene. |
| title_fullStr | Pathway and functional analysis of the hub gene. |
| title_full_unstemmed | Pathway and functional analysis of the hub gene. |
| title_short | Pathway and functional analysis of the hub gene. |
| title_sort | Pathway and functional analysis of the hub gene. |
| topic | Biochemistry Cell Biology Genetics Molecular Biology Immunology Biological Sciences not elsewhere classified spinal cord injury severely impacts motor programmed cell death div >< p debilitating neurological condition promising diagnostic potential potential therapeutic target 707 upregulated genes functional enrichment analysis gene expression omnibus panoptosis scores calculation identify hub genes consistently identified across panoptosis gene sets gene gsea analysis hub genes related gene potential drugs related genes elevated expression targeting panoptosis panoptosis score 23 panoptosis time pcr study seeks significantly higher significant roles significant challenges results underscore rat model quantitative real performed single patient quality pathways associated intersected degs inflammatory response immune response ihc ). healthy controls hc samples future studies experimentally confirm experimental validation emerging concept datasets gse151371 casp5 </ biological functions autonomic functions auc value |