Figure 2 from Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models

Figure 2 from Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models

<p>ART558 treatment leads to increased residual IR-induced DNA damage foci. <b>A,</b> γH2AX and 53BP1 foci in HCT116 and H460 cells treated with 3 μmol/L ART558 and 4 Gy IR, assessed at the indicated times points after IR. <b>B,</b> Representative images from irradiated...

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書目詳細資料
主要作者:	Gonzalo Rodriguez-Berriguete (15056057) (author)
其他作者:	Marco Ranzani (15056060) (author), Remko Prevo (15056063) (author), Rathi Puliyadi (15056066) (author), Nicole Machado (15056069) (author), Hannah R. Bolland (15056072) (author), Val Millar (15056075) (author), Daniel Ebner (15056078) (author), Marie Boursier (15056081) (author), Aurora Cerutti (15056084) (author), Alessandro Cicconi (15056087) (author), Alessandro Galbiati (15056090) (author), Diego Grande (15056093) (author), Vera Grinkevich (15056096) (author), Jayesh B. Majithiya (15056099) (author), Desiree Piscitello (15056102) (author), Eeson Rajendra (15056105) (author), Martin L. Stockley (15056108) (author), Simon J. Boulton (15056111) (author), Ester M. Hammond (15056114) (author), Robert A. Heald (15056117) (author), Graeme C.M. Smith (15056120) (author), Helen M.R. Robinson (15056123) (author), Geoff S. Higgins (15056126) (author)
出版:	2025
主題:	Cancer Molecular and Cellular Biology Therapeutic Research and Development DNA Damage and Repair DNA repair Radiation Oncology Molecular targets of radiation response Small Molecule Agents
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