Cellular compartment size determines the time delay for the inversely out-of-phase Ca2+-cAMP oscillation.

(A) The Ca2+ and cAMP dynamics for a double-width compartment. Dynamics on the AKAP/AC nanodomain (i) and at the edge of the compartment (ii) are shown. (B-C) Same plots as (A) except the compartment size. The compartment is doubled in height in (B) and doubled in bot...

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Bibliographic Details
Main Author:	Lingxia Qiao (19996756) (author)
Other Authors:	Michael Getz (17692612) (author), Ben Gross (2993145) (author), Brian Tenner (138904) (author), Jin Zhang (53297) (author), Padmini Rangamani (4740435) (author)
Published:	2024
Subjects:	Biophysics Biochemistry Microbiology Cell Biology Genetics Neuroscience Physiology Immunology Cancer Science Policy Biological Sciences not elsewhere classified previous experimental studies key circuit motif incoherent feedforward loop develop computational models adenylyl cyclase 8 two important predictions many cellular functions arbitrary phase difference div >< p camp peak simultaneously 2 +</ sup ac nanodomain formation phase oscillations associated enzymes associated two nanodomains ac nanodomains volume ratio turing pattern time delay spatiotemporal orchestration spatial compartmentation signaling molecules second messengers nanoscale organization low level governs camp give rise findings unveil ensuring compartmentation compartment size cellular surface camp oscillations
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Cellular compartment size determines the time delay for the inversely out-of-phase Ca<sup>2+</sup>-cAMP oscillation.

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