Validation of the PD diagnostic model in vitro.

Validation of the PD diagnostic model in vitro.

<p>(A-D) The expression level of 4 features in PD. (E-J) Western blot analysis the expression of TH, TFR, FTH, ACSL4 and GPX4 in SH-SY5Y cells treated by the 6-OHDA. (K-M) The levels of iron, MDA and GSH in SH-SY5Y cells treated by the 6-OHDA. (N-Q) The mRNA relative expression levels of GNGT1...

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Bibliographic Details
Main Author: Taole Li (20490462) (author)
Other Authors: Jifeng Guo (491535) (author)
Published: 2024
Subjects:
Cell Biology
Genetics
Molecular Biology
Biological Sciences not elsewhere classified
weight gene co
parkinson &# 8217
machine learning algorithms
five machine algorithms
experimental results showed
cell rna sequencing
97 substantia nigra
4 features (<
two subtypes based
diagnostic signatures based
entire pd cohort
certain diagnostic effect
xlink "> expression
complex neurodegenerative disease
characteristic signature genes
expression network analysis
pd diagnostic model
certain diagnostic
xlink ">
signature model
disease based
related genes
bioinformatics analysis
regulatory network
pd via
wgcna ),
vitro experiments
s100a2 axis
s100a2 </
recent studies
neurod4 </
might regulate
individual effects
gngt1 </
fcn2 </
degs ).
corresponding mirnas
close relationship
453 degs
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Summary:<p>(A-D) The expression level of 4 features in PD. (E-J) Western blot analysis the expression of TH, TFR, FTH, ACSL4 and GPX4 in SH-SY5Y cells treated by the 6-OHDA. (K-M) The levels of iron, MDA and GSH in SH-SY5Y cells treated by the 6-OHDA. (N-Q) The mRNA relative expression levels of GNGT1, FCN2, S100A2 and NEUROD4 in SH-SY5Y cells. (N = 3, *p < 0.05 vs Ctrl group, **p < 0.01 vs Ctrl group, ***p < 0.001 vs Ctrl group. #p < 0.05 vs 6-OHDA group, ##p < 0.01 vs 6-OHDA group, ###p < 0.001 vs 6-OHDA group).</p>

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