Supplementary file 1_Comparison of perioperative outcomes of open (CUSA) versus laparoscopic (LOTUS) major hepatectomy – revisited. First evaluation of efficacy and safety of AEON™ stapler.docx
Introduction<p>In 2019, preliminary data matching 20 laparoscopic (using LOTUS) with 20 open (using CUSA) cases demonstrated the feasibility and improved outcomes of laparoscopic major liver resections using the LOTUS™ liver blade. This updated study presents a larger comparison between open a...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , , |
| منشور في: |
2025
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1852018282586963968 |
|---|---|
| author | Affan Iqbal (21765872) |
| author2 | Minas Baltatzis (4963660) Panagiotis Stathakis (21765875) Jenifer Barrie (21765878) Ajith Kumar Siriwardena (21765881) Saurabh Jamdar (7055201) Aali Jan Sheen (21765884) |
| author2_role | author author author author author author |
| author_facet | Affan Iqbal (21765872) Minas Baltatzis (4963660) Panagiotis Stathakis (21765875) Jenifer Barrie (21765878) Ajith Kumar Siriwardena (21765881) Saurabh Jamdar (7055201) Aali Jan Sheen (21765884) |
| author_role | author |
| dc.creator.none.fl_str_mv | Affan Iqbal (21765872) Minas Baltatzis (4963660) Panagiotis Stathakis (21765875) Jenifer Barrie (21765878) Ajith Kumar Siriwardena (21765881) Saurabh Jamdar (7055201) Aali Jan Sheen (21765884) |
| dc.date.none.fl_str_mv | 2025-07-23T04:11:35Z |
| dc.identifier.none.fl_str_mv | 10.3389/fonc.2025.1616876.s001 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/Supplementary_file_1_Comparison_of_perioperative_outcomes_of_open_CUSA_versus_laparoscopic_LOTUS_major_hepatectomy_revisited_First_evaluation_of_efficacy_and_safety_of_AEON_stapler_docx/29623391 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Oncology and Carcinogenesis not elsewhere classified LOTUS liver energy laparoscopic liver resection AEON endovascular stapler major hepatectomy propensity score matching |
| dc.title.none.fl_str_mv | Supplementary file 1_Comparison of perioperative outcomes of open (CUSA) versus laparoscopic (LOTUS) major hepatectomy – revisited. First evaluation of efficacy and safety of AEON™ stapler.docx |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | Introduction<p>In 2019, preliminary data matching 20 laparoscopic (using LOTUS) with 20 open (using CUSA) cases demonstrated the feasibility and improved outcomes of laparoscopic major liver resections using the LOTUS™ liver blade. This updated study presents a larger comparison between open and laparoscopic major hepatectomies and, for the first time, evaluates the safety of the endovascular stapler AEON™ (Lexington Medical, Massachusetts, USA).</p>Methods<p>All consecutive patients who underwent liver resections, both open and laparoscopic, from January 2020 to June 2023 were identified from a prospectively maintained database. Propensity score matching was performed to identify matched open and laparoscopic cases, which were compared for intra- and post-operative short-term outcomes. The LOTUS™ ultrasonic energy device was used for transection in laparoscopic cases, whereas CUSA was used in open procedures. AEON was introduced in 2021 and compared with the previously used stapler.</p>Results<p>The initial sample of 116 patients was narrowed to 86 after applying 1:1 matching. The median age was 63 years (range 27–83). Laparoscopic cases showed reduced hospital stay (mean 7.8 vs. 14.7 days; p = 0.025), increased Pringle time (48.5 vs. 33 minutes; p = 0.010), and reduced transfusion requirements (0 vs. 4 units; p = 0.035). Comparing AEON™ with Endo-GIA showed no statistical differences, though AEON™ showed a possible trend toward reduced transection time overall (56 vs. 69 minutes; p = 0.300) and in laparoscopic cases (56 vs. 71 minutes; p = 0.295).</p>Conclusion<p>The LOTUS™ liver blade continues to demonstrate safety and efficacy in laparoscopic liver resections. Transection time has improved compared to the earlier study, likely reflecting increased experience. AEON™ is shown to be non-inferior for vessel ligation, with a potential trend toward reduced transection time in both open and laparoscopic cases.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_2e414f8a2dd67d2922655e19a5ed88cf |
| identifier_str_mv | 10.3389/fonc.2025.1616876.s001 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/29623391 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Supplementary file 1_Comparison of perioperative outcomes of open (CUSA) versus laparoscopic (LOTUS) major hepatectomy – revisited. First evaluation of efficacy and safety of AEON™ stapler.docxAffan Iqbal (21765872)Minas Baltatzis (4963660)Panagiotis Stathakis (21765875)Jenifer Barrie (21765878)Ajith Kumar Siriwardena (21765881)Saurabh Jamdar (7055201)Aali Jan Sheen (21765884)Oncology and Carcinogenesis not elsewhere classifiedLOTUS liver energylaparoscopic liver resectionAEON endovascular staplermajor hepatectomypropensity score matchingIntroduction<p>In 2019, preliminary data matching 20 laparoscopic (using LOTUS) with 20 open (using CUSA) cases demonstrated the feasibility and improved outcomes of laparoscopic major liver resections using the LOTUS™ liver blade. This updated study presents a larger comparison between open and laparoscopic major hepatectomies and, for the first time, evaluates the safety of the endovascular stapler AEON™ (Lexington Medical, Massachusetts, USA).</p>Methods<p>All consecutive patients who underwent liver resections, both open and laparoscopic, from January 2020 to June 2023 were identified from a prospectively maintained database. Propensity score matching was performed to identify matched open and laparoscopic cases, which were compared for intra- and post-operative short-term outcomes. The LOTUS™ ultrasonic energy device was used for transection in laparoscopic cases, whereas CUSA was used in open procedures. AEON was introduced in 2021 and compared with the previously used stapler.</p>Results<p>The initial sample of 116 patients was narrowed to 86 after applying 1:1 matching. The median age was 63 years (range 27–83). Laparoscopic cases showed reduced hospital stay (mean 7.8 vs. 14.7 days; p = 0.025), increased Pringle time (48.5 vs. 33 minutes; p = 0.010), and reduced transfusion requirements (0 vs. 4 units; p = 0.035). Comparing AEON™ with Endo-GIA showed no statistical differences, though AEON™ showed a possible trend toward reduced transection time overall (56 vs. 69 minutes; p = 0.300) and in laparoscopic cases (56 vs. 71 minutes; p = 0.295).</p>Conclusion<p>The LOTUS™ liver blade continues to demonstrate safety and efficacy in laparoscopic liver resections. Transection time has improved compared to the earlier study, likely reflecting increased experience. AEON™ is shown to be non-inferior for vessel ligation, with a potential trend toward reduced transection time in both open and laparoscopic cases.</p>2025-07-23T04:11:35ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.3389/fonc.2025.1616876.s001https://figshare.com/articles/dataset/Supplementary_file_1_Comparison_of_perioperative_outcomes_of_open_CUSA_versus_laparoscopic_LOTUS_major_hepatectomy_revisited_First_evaluation_of_efficacy_and_safety_of_AEON_stapler_docx/29623391CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/296233912025-07-23T04:11:35Z |
| spellingShingle | Supplementary file 1_Comparison of perioperative outcomes of open (CUSA) versus laparoscopic (LOTUS) major hepatectomy – revisited. First evaluation of efficacy and safety of AEON™ stapler.docx Affan Iqbal (21765872) Oncology and Carcinogenesis not elsewhere classified LOTUS liver energy laparoscopic liver resection AEON endovascular stapler major hepatectomy propensity score matching |
| status_str | publishedVersion |
| title | Supplementary file 1_Comparison of perioperative outcomes of open (CUSA) versus laparoscopic (LOTUS) major hepatectomy – revisited. First evaluation of efficacy and safety of AEON™ stapler.docx |
| title_full | Supplementary file 1_Comparison of perioperative outcomes of open (CUSA) versus laparoscopic (LOTUS) major hepatectomy – revisited. First evaluation of efficacy and safety of AEON™ stapler.docx |
| title_fullStr | Supplementary file 1_Comparison of perioperative outcomes of open (CUSA) versus laparoscopic (LOTUS) major hepatectomy – revisited. First evaluation of efficacy and safety of AEON™ stapler.docx |
| title_full_unstemmed | Supplementary file 1_Comparison of perioperative outcomes of open (CUSA) versus laparoscopic (LOTUS) major hepatectomy – revisited. First evaluation of efficacy and safety of AEON™ stapler.docx |
| title_short | Supplementary file 1_Comparison of perioperative outcomes of open (CUSA) versus laparoscopic (LOTUS) major hepatectomy – revisited. First evaluation of efficacy and safety of AEON™ stapler.docx |
| title_sort | Supplementary file 1_Comparison of perioperative outcomes of open (CUSA) versus laparoscopic (LOTUS) major hepatectomy – revisited. First evaluation of efficacy and safety of AEON™ stapler.docx |
| topic | Oncology and Carcinogenesis not elsewhere classified LOTUS liver energy laparoscopic liver resection AEON endovascular stapler major hepatectomy propensity score matching |