Figure 4 from Impact of Duration of Neoadjuvant Aromatase Inhibitors on Molecular Expression Profiles in Estrogen Receptor–positive Breast Cancers
<p>Single-gene expression changes of genes in common between baseline and surgery in the different cohorts. <b>A,</b> Scatterplot of differentially expressed genes between baseline and surgery measured by log<sub>2</sub> FC among the entire short-term and long-term AI c...
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2025
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| _version_ | 1849927634764431360 |
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| author | Milana A. Bergamino (15038015) |
| author2 | Gabriele Morani (15038018) Joel Parker (15038021) Eugene F. Schuster (9726535) Mariana F. Leal (15038024) Elena López-Knowles (15038027) Holly Tovey (9360536) Judith M. Bliss (8827107) John F.R. Robertson (15025368) Ian E. Smith (1545553) Mitch Dowsett (645) Maggie C.U. Cheang (14946768) |
| author2_role | author author author author author author author author author author author |
| author_facet | Milana A. Bergamino (15038015) Gabriele Morani (15038018) Joel Parker (15038021) Eugene F. Schuster (9726535) Mariana F. Leal (15038024) Elena López-Knowles (15038027) Holly Tovey (9360536) Judith M. Bliss (8827107) John F.R. Robertson (15025368) Ian E. Smith (1545553) Mitch Dowsett (645) Maggie C.U. Cheang (14946768) |
| author_role | author |
| dc.creator.none.fl_str_mv | Milana A. Bergamino (15038015) Gabriele Morani (15038018) Joel Parker (15038021) Eugene F. Schuster (9726535) Mariana F. Leal (15038024) Elena López-Knowles (15038027) Holly Tovey (9360536) Judith M. Bliss (8827107) John F.R. Robertson (15025368) Ian E. Smith (1545553) Mitch Dowsett (645) Maggie C.U. Cheang (14946768) |
| dc.date.none.fl_str_mv | 2025-11-25T12:05:26Z |
| dc.identifier.none.fl_str_mv | 10.1158/1078-0432.30705371 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Figure_4_from_Impact_of_Duration_of_Neoadjuvant_Aromatase_Inhibitors_on_Molecular_Expression_Profiles_in_Estrogen_Receptor_positive_Breast_Cancers/30705371 |
| dc.rights.none.fl_str_mv | CC BY info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Cancer Tumor Biology Cancer Detection and Diagnosis Therapeutic Research and Development Biomarkers Genetic biomarkers Breast Cancer Drug Resistance Novel mechanisms Endocrinology Translational Research |
| dc.title.none.fl_str_mv | Figure 4 from Impact of Duration of Neoadjuvant Aromatase Inhibitors on Molecular Expression Profiles in Estrogen Receptor–positive Breast Cancers |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>Single-gene expression changes of genes in common between baseline and surgery in the different cohorts. <b>A,</b> Scatterplot of differentially expressed genes between baseline and surgery measured by log<sub>2</sub> FC among the entire short-term and long-term AI cohorts. <b>B,</b> Scatterplot of differentially expressed genes between baseline and surgery measured by log<sub>2</sub> FC among Luminal B–treated tumors only in the short-term and long-term AI cohorts <b>C,</b> Boxplot showing the intersections of common genes differentially expressed between baseline and surgery among different combinations of subgroups of sample patients within the POETIC and NeoAI cohorts: all treated patients in POETIC, only treated with Luminal A in POETIC, only treated with Luminal B in POETIC, all patients in NeoAI, only Luminal A in NeoAI, only Luminal B patients in NeoAI, only controls in POETIC. FDR, false discovery rate; log<sub>2</sub> FC, log<sub>2</sub> fold change.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_2e591507e55456020c4a6672f7471421 |
| identifier_str_mv | 10.1158/1078-0432.30705371 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30705371 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY |
| spelling | Figure 4 from Impact of Duration of Neoadjuvant Aromatase Inhibitors on Molecular Expression Profiles in Estrogen Receptor–positive Breast CancersMilana A. Bergamino (15038015)Gabriele Morani (15038018)Joel Parker (15038021)Eugene F. Schuster (9726535)Mariana F. Leal (15038024)Elena López-Knowles (15038027)Holly Tovey (9360536)Judith M. Bliss (8827107)John F.R. Robertson (15025368)Ian E. Smith (1545553)Mitch Dowsett (645)Maggie C.U. Cheang (14946768)CancerTumor BiologyCancer Detection and DiagnosisTherapeutic Research and DevelopmentBiomarkersGenetic biomarkersBreast CancerDrug ResistanceNovel mechanismsEndocrinologyTranslational Research<p>Single-gene expression changes of genes in common between baseline and surgery in the different cohorts. <b>A,</b> Scatterplot of differentially expressed genes between baseline and surgery measured by log<sub>2</sub> FC among the entire short-term and long-term AI cohorts. <b>B,</b> Scatterplot of differentially expressed genes between baseline and surgery measured by log<sub>2</sub> FC among Luminal B–treated tumors only in the short-term and long-term AI cohorts <b>C,</b> Boxplot showing the intersections of common genes differentially expressed between baseline and surgery among different combinations of subgroups of sample patients within the POETIC and NeoAI cohorts: all treated patients in POETIC, only treated with Luminal A in POETIC, only treated with Luminal B in POETIC, all patients in NeoAI, only Luminal A in NeoAI, only Luminal B patients in NeoAI, only controls in POETIC. FDR, false discovery rate; log<sub>2</sub> FC, log<sub>2</sub> fold change.</p>2025-11-25T12:05:26ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1158/1078-0432.30705371https://figshare.com/articles/figure/Figure_4_from_Impact_of_Duration_of_Neoadjuvant_Aromatase_Inhibitors_on_Molecular_Expression_Profiles_in_Estrogen_Receptor_positive_Breast_Cancers/30705371CC BYinfo:eu-repo/semantics/openAccessoai:figshare.com:article/307053712025-11-25T12:05:26Z |
| spellingShingle | Figure 4 from Impact of Duration of Neoadjuvant Aromatase Inhibitors on Molecular Expression Profiles in Estrogen Receptor–positive Breast Cancers Milana A. Bergamino (15038015) Cancer Tumor Biology Cancer Detection and Diagnosis Therapeutic Research and Development Biomarkers Genetic biomarkers Breast Cancer Drug Resistance Novel mechanisms Endocrinology Translational Research |
| status_str | publishedVersion |
| title | Figure 4 from Impact of Duration of Neoadjuvant Aromatase Inhibitors on Molecular Expression Profiles in Estrogen Receptor–positive Breast Cancers |
| title_full | Figure 4 from Impact of Duration of Neoadjuvant Aromatase Inhibitors on Molecular Expression Profiles in Estrogen Receptor–positive Breast Cancers |
| title_fullStr | Figure 4 from Impact of Duration of Neoadjuvant Aromatase Inhibitors on Molecular Expression Profiles in Estrogen Receptor–positive Breast Cancers |
| title_full_unstemmed | Figure 4 from Impact of Duration of Neoadjuvant Aromatase Inhibitors on Molecular Expression Profiles in Estrogen Receptor–positive Breast Cancers |
| title_short | Figure 4 from Impact of Duration of Neoadjuvant Aromatase Inhibitors on Molecular Expression Profiles in Estrogen Receptor–positive Breast Cancers |
| title_sort | Figure 4 from Impact of Duration of Neoadjuvant Aromatase Inhibitors on Molecular Expression Profiles in Estrogen Receptor–positive Breast Cancers |
| topic | Cancer Tumor Biology Cancer Detection and Diagnosis Therapeutic Research and Development Biomarkers Genetic biomarkers Breast Cancer Drug Resistance Novel mechanisms Endocrinology Translational Research |