Description of systems studied.

Description of systems studied.

<p>The composition of the bilayer in the <i>Surface</i> model was set as 55% DOPC, 21% DPPE, 11% POPI, 9% cholesterol and 4% DOPS. Each membrane contained 1200 total lipids (600 per leaflet).</p> <p>(XLSX)</p>

محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Oluwatoyin Campbell (14392137) (author)
مؤلفون آخرون:	Dina Dahhan (22683620) (author), Viviana Monje (2056069) (author)
منشور في:	2025
الموضوعات:	Biophysics Biochemistry Cell Biology Genetics Molecular Biology Biotechnology Cancer Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Physical Sciences not elsewhere classified Information Systems not elsewhere classified process may help complex transmembrane topology comparing dimer interactions aqueous solution versus promote p7 oligomerization protein residue alignment p7 dimers driven alignment underlie health study demonstrates particularly involving often composed molecular mechanisms key residues hydrophobic contacts hydrogen bonding first helix explain assembly dynamic contributors channel assembly
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!

مواد مشابهة

Suggested mechanism of p7 dimerization at the ER membrane surface, based on results from this study.
حسب: Oluwatoyin Campbell (14392137)
منشور في: (2025)

Correlation of protein and lipid motions in the <i>Surface</i> model.
حسب: Oluwatoyin Campbell (14392137)
منشور في: (2025)

Protein-lipid interactions in the <i>Surface</i> model.
حسب: Oluwatoyin Campbell (14392137)
منشور في: (2025)

Energetics of protein interactions.
حسب: Oluwatoyin Campbell (14392137)
منشور في: (2025)

Residue contact comparison with reference dimer structure.
حسب: Oluwatoyin Campbell (14392137)
منشور في: (2025)

Protein conformational dynamics induced by presence of a lipid membrane.
حسب: Oluwatoyin Campbell (14392137)
منشور في: (2025)

Initial simulation coordinates. A) p7 amino acids and their corresponding position within the protein. B) Two p7 monomers separated (<i>Sep</i> model) and C) extracted from the hexameric structure PDBID 2M6X (initial <i>Bound</i> model configuration). D) Two monomers initially attached by N-termini to the surface of a complex membrane (<i>Surface</i> model) containing DOPC (in green), DPPE (in blue), POPI (in purple), Cholesterol (in black) and DOPS (in orange) (55:21:11:9:4 mol%). Monomers are in the initial positioning seen in replica 1. Water atoms shown with sky blue. Proteins are shown with cartoon representation and differentiated in pink and ice-blue (p1 and p2, respectively); when shown, non-polar residues in white, polar in green and cationic in blue. In snapshots, water and ions are omitted for clarity.
حسب: Oluwatoyin Campbell (14392137)
منشور في: (2025)

Protein-lipid dynamic cross correlation maps for <i>Surface</i> replicas 2 and 4 during the entire trajectory.
حسب: Oluwatoyin Campbell (14392137)
منشور في: (2025)

Frequency of hydrogen bonds between individual residues and lipid species during the last half of trajectory (500 ns) in the <i>Surface</i> model.
حسب: Oluwatoyin Campbell (14392137)
منشور في: (2025)

Snapshot showing cholesterol contacts with the N-terminus of p2 and H2 and H3 of p1 in the <i>Surface</i> model.
حسب: Oluwatoyin Campbell (14392137)
منشور في: (2025)

Coulomb (electrostatic), Lennard-Jones (hydrophobic), and total interaction energy of interacting monomer helices in each model.
حسب: Oluwatoyin Campbell (14392137)
منشور في: (2025)

Surface replica 4 structural evaluation.
حسب: Oluwatoyin Campbell (14392137)
منشور في: (2025)

Tilt angle conformational landscapes of residues involved in 1-to-1 helix contacts during the last 500 ns of trajectory in the <i>Surface</i> model.
حسب: Oluwatoyin Campbell (14392137)
منشور في: (2025)

Tilt angle conformational landscapes of residues involved in 1-to-1 helix contacts during the last 200 ns of trajectory in the <i>Sep</i> model.
حسب: Oluwatoyin Campbell (14392137)
منشور في: (2025)

Contact maps of residues during the last half of trajectory (200 ns in <i>Sep</i> and 500 ns in <i>Surface</i> model), based on a cutoff of 14 Å.
حسب: Oluwatoyin Campbell (14392137)
منشور في: (2025)

Distance of each amino acid from the average position of phosphorus atoms in the contacting membrane leaflet in the <i>Surface</i> systems.
حسب: Oluwatoyin Campbell (14392137)
منشور في: (2025)

RMSF per residue in individual p7 monomers for each <i>Sep</i> and <i>Surface</i> model replica.
حسب: Oluwatoyin Campbell (14392137)
منشور في: (2025)

Root mean square deviation measurements of monomers.
حسب: Oluwatoyin Campbell (14392137)
منشور في: (2025)

Deviations of the <i>Bound</i> model protein dimer conformation from the reference crystal structure of the channel (PDBID: 2M6X).
حسب: Oluwatoyin Campbell (14392137)
منشور في: (2025)

Initial positioning of monomers in replicas 1, 2, 3 and 4 of <i>Surface</i> model.
حسب: Oluwatoyin Campbell (14392137)
منشور في: (2025)

List of protein residues and selected atoms to define the tilt angle vectors.
حسب: Oluwatoyin Campbell (14392137)
منشور في: (2025)

Long-Range Destabilizing Effects of Mutations at the <i>Escherichia coli</i> β Clamp Dimer Interface
حسب: Melissa L. Liriano (3967124)
منشور في: (2025)

De Novo Design of Mirror-Image Dimeric Antimicrobial Peptides with Low Drug Resistance and In Vivo Efficacy
حسب: Jingying Zhang (1637071)
منشور في: (2025)

Structural Evidence of Interanionic Hydrogen Bonding in Phosphoric Acid Solutions
حسب: Pyeongeun Kim (9509954)
منشور في: (2025)

Ultrafast and Ultraslow Proton-Transfer Dynamics Induced by Formic Acid Dimer Ionization
حسب: Saroj Barik (20091891)
منشور في: (2025)

Rocker-Switch Mechanism of Choline Transmembrane Transport in FLVCR2: Dynamic Latch Residues and Cooperative Regulation of Transmembrane Helices
حسب: Xiaoyu Zhao (197804)
منشور في: (2025)

Staircase Alignment of Phosphacoumarin Dimers as Alternate <i>n</i>- and <i>p</i>‑Type Organic Semiconductors for Photocurrent Generation
حسب: Md Azimuddin Sk (19768208)
منشور في: (2025)

Macroscopic Alignment and Structural Fixation of Homogeneous Cross-Linked Polymer Networks for Ultrastrong Hydrogels
حسب: Peipei Ma (360336)
منشور في: (2025)

Macroscopic Alignment and Structural Fixation of Homogeneous Cross-Linked Polymer Networks for Ultrastrong Hydrogels
حسب: Peipei Ma (360336)
منشور في: (2025)

Macroscopic Alignment and Structural Fixation of Homogeneous Cross-Linked Polymer Networks for Ultrastrong Hydrogels
حسب: Peipei Ma (360336)
منشور في: (2025)

Macroscopic Alignment and Structural Fixation of Homogeneous Cross-Linked Polymer Networks for Ultrastrong Hydrogels
حسب: Peipei Ma (360336)
منشور في: (2025)

Exploring the Conformational Landscape of Complexes with Cucurbit[8]uril and Aromatic Peptide Dimers by Ion Mobility Mass Spectrometry and Theoretical Calculations
حسب: Jianglong Du (18592417)
منشور في: (2025)

Self-Assembly Precedes Target Membrane Recruitment of a Nuclear Dynamin-Related Protein
حسب: Sakti Ranjan Rout (22304030)
منشور في: (2025)

Summary of transgenic <i>T. brucei</i> cell lines used in this study.
حسب: Philip Stettler (12884656)
منشور في: (2025)

Assembly model of the OM TAC module.
حسب: Philip Stettler (12884656)
منشور في: (2025)

Predicted structure of the TAC40 oligomer.
حسب: Philip Stettler (12884656)
منشور في: (2025)

The TAC60 N-terminus is essential for the integrity of the OM TAC module.
حسب: Philip Stettler (12884656)
منشور في: (2025)

Rapid de novo formation of TAC40-containing subcomplexes.
حسب: Philip Stettler (12884656)
منشور في: (2025)

TAC OM module subcomplexes form independently of cytosolic and inner TAC modules.
حسب: Philip Stettler (12884656)
منشور في: (2025)

The two classes of OM TAC module subcomplexes form independently. (A) Immunoblots of BN-PAGE experiments probed for TAC40 of cell lines with inducible pATOM36 (left) or TAC65 (right) knockdown. (B) As in (A) but immunoblots of TAC40 depleted cells probed for TAC65-myc (left) and pATOM36-HA (right) with anti-tag antibodies are shown.
حسب: Philip Stettler (12884656)
منشور في: (2025)