Tonic inhibition reduces LTP amplitude but maintains proximal potentiation and frequency dependence.

Effect of tonic inhibition on distance and frequency dependence of long-term potentiation. (a–c): Induction of LTP with 10 Hz 900 pulse protocol with varying tonic inhibition conductances (0.5–1 x 10−4 S/cm2, corresponding to 20–40 pA). (d) Freq...

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Autor Principal:	Nicholas Hananeia (22683665) (author)
Outros autores:	Christian Ebner (1276467) (author), Christos Galanis (15210328) (author), Hermann Cuntz (32618) (author), Alexander Opitz (295799) (author), Andreas Vlachos (47497) (author), Peter Jedlicka (179938) (author)
Publicado:	2025
Subjects:	Medicine Cell Biology Neuroscience Physiology Space Science Biological Sciences not elsewhere classified Information Systems not elsewhere classified results :</ b previous experimental studies objective :</ b methods :</ b like cellular effects conclusion :</ b background :</ b strongly distance dependent scale modeling tools repetitive magnetic stimulation biophysical neuronal models 1 hz protocols successfully modelled plasticity induced synaptic plasticity dependent plasticity model plasticity model dependent spatio scale modelling burst stimulation 5 hz plasticity amplitude distal plasticity term potentiation term changes temporal resolution temporal changes rms ). previously established parameter screening neurons stimulated neuronal dendrites modelling framework mechanisms behind low sensitivity high spatio fully understood detailed prediction dendritic spikes comprehensive module
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Summary:	<p>Effect of tonic inhibition on distance and frequency dependence of long-term potentiation. (a–c): Induction of LTP with 10 Hz 900 pulse protocol with varying tonic inhibition conductances (0.5–1 x 10<sup>−4</sup> S/cm<sup>2</sup>, corresponding to 20–40 pA). (d) Frequency dependence of proximal LTP induction with different tonic inhibition conductances from variable frequency 900 pulse protocol.</p> <p>(TIFF)</p>

Tonic inhibition reduces LTP amplitude but maintains proximal potentiation and frequency dependence.

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