Tonic inhibition reduces LTP amplitude but maintains proximal potentiation and frequency dependence.

Tonic inhibition reduces LTP amplitude but maintains proximal potentiation and frequency dependence.

<p>Effect of tonic inhibition on distance and frequency dependence of long-term potentiation. (a–c): Induction of LTP with 10 Hz 900 pulse protocol with varying tonic inhibition conductances (0.5–1 x 10<sup>−4</sup> S/cm<sup>2</sup>, corresponding to 20–40 pA). (d) Freq...

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Bibliografski detalji
Glavni autor: Nicholas Hananeia (22683665) (author)
Daljnji autori: Christian Ebner (1276467) (author), Christos Galanis (15210328) (author), Hermann Cuntz (32618) (author), Alexander Opitz (295799) (author), Andreas Vlachos (47497) (author), Peter Jedlicka (179938) (author)
Izdano: 2025
Teme:
Medicine
Cell Biology
Neuroscience
Physiology
Space Science
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
results :</ b
previous experimental studies
objective :</ b
methods :</ b
like cellular effects
conclusion :</ b
background :</ b
strongly distance dependent
scale modeling tools
repetitive magnetic stimulation
biophysical neuronal models
1 hz protocols
successfully modelled plasticity
induced synaptic plasticity
dependent plasticity model
plasticity model
dependent spatio
scale modelling
burst stimulation
5 hz
plasticity amplitude
distal plasticity
term potentiation
term changes
temporal resolution
temporal changes
rms ).
previously established
parameter screening
neurons stimulated
neuronal dendrites
modelling framework
mechanisms behind
low sensitivity
high spatio
fully understood
detailed prediction
dendritic spikes
comprehensive module
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Sažetak:<p>Effect of tonic inhibition on distance and frequency dependence of long-term potentiation. (a–c): Induction of LTP with 10 Hz 900 pulse protocol with varying tonic inhibition conductances (0.5–1 x 10<sup>−4</sup> S/cm<sup>2</sup>, corresponding to 20–40 pA). (d) Frequency dependence of proximal LTP induction with different tonic inhibition conductances from variable frequency 900 pulse protocol.</p> <p>(TIFF)</p>

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