Tonic inhibition reduces LTP amplitude but maintains proximal potentiation and frequency dependence.
<p>Effect of tonic inhibition on distance and frequency dependence of long-term potentiation. (a–c): Induction of LTP with 10 Hz 900 pulse protocol with varying tonic inhibition conductances (0.5–1 x 10<sup>−4</sup> S/cm<sup>2</sup>, corresponding to 20–40 pA). (d) Freq...
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2025
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| _version_ | 1849927626309763072 |
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| author | Nicholas Hananeia (22683665) |
| author2 | Christian Ebner (1276467) Christos Galanis (15210328) Hermann Cuntz (32618) Alexander Opitz (295799) Andreas Vlachos (47497) Peter Jedlicka (179938) |
| author2_role | author author author author author author |
| author_facet | Nicholas Hananeia (22683665) Christian Ebner (1276467) Christos Galanis (15210328) Hermann Cuntz (32618) Alexander Opitz (295799) Andreas Vlachos (47497) Peter Jedlicka (179938) |
| author_role | author |
| dc.creator.none.fl_str_mv | Nicholas Hananeia (22683665) Christian Ebner (1276467) Christos Galanis (15210328) Hermann Cuntz (32618) Alexander Opitz (295799) Andreas Vlachos (47497) Peter Jedlicka (179938) |
| dc.date.none.fl_str_mv | 2025-11-25T18:41:57Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pcbi.1012295.s004 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Tonic_inhibition_reduces_LTP_amplitude_but_maintains_proximal_potentiation_and_frequency_dependence_/30714998 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Medicine Cell Biology Neuroscience Physiology Space Science Biological Sciences not elsewhere classified Information Systems not elsewhere classified results :</ b previous experimental studies objective :</ b methods :</ b like cellular effects conclusion :</ b background :</ b strongly distance dependent scale modeling tools repetitive magnetic stimulation biophysical neuronal models 1 hz protocols successfully modelled plasticity induced synaptic plasticity dependent plasticity model plasticity model dependent spatio scale modelling burst stimulation 5 hz plasticity amplitude distal plasticity term potentiation term changes temporal resolution temporal changes rms ). previously established parameter screening neurons stimulated neuronal dendrites modelling framework mechanisms behind low sensitivity high spatio fully understood detailed prediction dendritic spikes comprehensive module |
| dc.title.none.fl_str_mv | Tonic inhibition reduces LTP amplitude but maintains proximal potentiation and frequency dependence. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>Effect of tonic inhibition on distance and frequency dependence of long-term potentiation. (a–c): Induction of LTP with 10 Hz 900 pulse protocol with varying tonic inhibition conductances (0.5–1 x 10<sup>−4</sup> S/cm<sup>2</sup>, corresponding to 20–40 pA). (d) Frequency dependence of proximal LTP induction with different tonic inhibition conductances from variable frequency 900 pulse protocol.</p> <p>(TIFF)</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_2ea660079288ebccf930b31795715576 |
| identifier_str_mv | 10.1371/journal.pcbi.1012295.s004 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30714998 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Tonic inhibition reduces LTP amplitude but maintains proximal potentiation and frequency dependence.Nicholas Hananeia (22683665)Christian Ebner (1276467)Christos Galanis (15210328)Hermann Cuntz (32618)Alexander Opitz (295799)Andreas Vlachos (47497)Peter Jedlicka (179938)MedicineCell BiologyNeurosciencePhysiologySpace ScienceBiological Sciences not elsewhere classifiedInformation Systems not elsewhere classifiedresults :</ bprevious experimental studiesobjective :</ bmethods :</ blike cellular effectsconclusion :</ bbackground :</ bstrongly distance dependentscale modeling toolsrepetitive magnetic stimulationbiophysical neuronal models1 hz protocolssuccessfully modelled plasticityinduced synaptic plasticitydependent plasticity modelplasticity modeldependent spatioscale modellingburst stimulation5 hzplasticity amplitudedistal plasticityterm potentiationterm changestemporal resolutiontemporal changesrms ).previously establishedparameter screeningneurons stimulatedneuronal dendritesmodelling frameworkmechanisms behindlow sensitivityhigh spatiofully understooddetailed predictiondendritic spikescomprehensive module<p>Effect of tonic inhibition on distance and frequency dependence of long-term potentiation. (a–c): Induction of LTP with 10 Hz 900 pulse protocol with varying tonic inhibition conductances (0.5–1 x 10<sup>−4</sup> S/cm<sup>2</sup>, corresponding to 20–40 pA). (d) Frequency dependence of proximal LTP induction with different tonic inhibition conductances from variable frequency 900 pulse protocol.</p> <p>(TIFF)</p>2025-11-25T18:41:57ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pcbi.1012295.s004https://figshare.com/articles/figure/Tonic_inhibition_reduces_LTP_amplitude_but_maintains_proximal_potentiation_and_frequency_dependence_/30714998CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/307149982025-11-25T18:41:57Z |
| spellingShingle | Tonic inhibition reduces LTP amplitude but maintains proximal potentiation and frequency dependence. Nicholas Hananeia (22683665) Medicine Cell Biology Neuroscience Physiology Space Science Biological Sciences not elsewhere classified Information Systems not elsewhere classified results :</ b previous experimental studies objective :</ b methods :</ b like cellular effects conclusion :</ b background :</ b strongly distance dependent scale modeling tools repetitive magnetic stimulation biophysical neuronal models 1 hz protocols successfully modelled plasticity induced synaptic plasticity dependent plasticity model plasticity model dependent spatio scale modelling burst stimulation 5 hz plasticity amplitude distal plasticity term potentiation term changes temporal resolution temporal changes rms ). previously established parameter screening neurons stimulated neuronal dendrites modelling framework mechanisms behind low sensitivity high spatio fully understood detailed prediction dendritic spikes comprehensive module |
| status_str | publishedVersion |
| title | Tonic inhibition reduces LTP amplitude but maintains proximal potentiation and frequency dependence. |
| title_full | Tonic inhibition reduces LTP amplitude but maintains proximal potentiation and frequency dependence. |
| title_fullStr | Tonic inhibition reduces LTP amplitude but maintains proximal potentiation and frequency dependence. |
| title_full_unstemmed | Tonic inhibition reduces LTP amplitude but maintains proximal potentiation and frequency dependence. |
| title_short | Tonic inhibition reduces LTP amplitude but maintains proximal potentiation and frequency dependence. |
| title_sort | Tonic inhibition reduces LTP amplitude but maintains proximal potentiation and frequency dependence. |
| topic | Medicine Cell Biology Neuroscience Physiology Space Science Biological Sciences not elsewhere classified Information Systems not elsewhere classified results :</ b previous experimental studies objective :</ b methods :</ b like cellular effects conclusion :</ b background :</ b strongly distance dependent scale modeling tools repetitive magnetic stimulation biophysical neuronal models 1 hz protocols successfully modelled plasticity induced synaptic plasticity dependent plasticity model plasticity model dependent spatio scale modelling burst stimulation 5 hz plasticity amplitude distal plasticity term potentiation term changes temporal resolution temporal changes rms ). previously established parameter screening neurons stimulated neuronal dendrites modelling framework mechanisms behind low sensitivity high spatio fully understood detailed prediction dendritic spikes comprehensive module |