SPION+ SIV-RNA+ macrophages in the parenchyma, meninges, choroid plexus, dCLN, spleen, and DRG of animals with AIDS and SIVE.

SIV-RNA (red) was detected in the CNS perivascular space, meninges, choroid plexus, and outside of the CNS in the dCLN, spleen, and DRG using RNAscope in situ hybridization. Early (green) SPION were i.c. injected 12-14 dpi and Late (pseudo-colored colored blue) SPION were i.c. injected 30 d...

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Автор:	Zoey K. Wallis (17725175) (author)
Інші автори:	Cecily C. Midkiff (11083425) (author), Miaoyun Zhao (18996267) (author), Patrick Autissier (93068) (author), Soon Ok Kim (22756434) (author), Addison Q. Amadeck (22756437) (author), Yiwei Wang (403386) (author), Maia Jakubowski (22756440) (author), Tricia H. Burdo (9592101) (author), Andrew D. Miller (328799) (author), Qingsheng Li (515132) (author), Xavier Alvarez (33185) (author), Robert V. Blair (11722847) (author), Kenneth C. Williams (11527354) (author)
Опубліковано:	2025
Предмети:	Medicine Microbiology Neuroscience Immunology Infectious Diseases Plant Biology Virology Environmental Sciences not elsewhere classified sup >+</ sup simian immunodeficiency virus peripheral sites including myeloid cell egress human immunodeficiency virus dorsal root ganglia central nervous system track macrophage turnover observed higher numbers labeled macrophages within div >< p cns viral reservoirs art reduces trafficking cns </ p perivascular macrophage reservoir following art interruption meningeal macrophages persisted meningeal macrophages increased choroid plexus macrophages art eliminated siv scattered viral rna choroid plexus macrophage traffic art interruption meningeal macrophages trafficking diminished scattered siv low numbers treatment interruption perivascular macrophages macrophages trafficked infected macrophages viral infection art treatment art decreased preferentially taken lesser extent infected macaques findings support enabling us c .) assess establishment antiretroviral therapy administered intracisternal 30 days
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Резюме:	<p>SIV-RNA (red) was detected in the CNS perivascular space, meninges, choroid plexus, and outside of the CNS in the dCLN, spleen, and DRG using RNAscope in situ hybridization. Early (green) SPION were i.c. injected 12-14 dpi and Late (pseudo-colored colored blue) SPION were i.c. injected 30 days prior to sacrifice. Images were captured from scanned tissue sections. Nuclei (gray) are stained with DAPI.</p>

SPION<sup>+</sup> SIV-RNA<sup>+</sup> macrophages in the parenchyma, meninges, choroid plexus, dCLN, spleen, and DRG of animals with AIDS and SIVE.

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