SPION<sup>+</sup> SIV-RNA<sup>+</sup> macrophages in the parenchyma, meninges, choroid plexus, dCLN, spleen, and DRG of animals with AIDS and SIVE.

SPION<sup>+</sup> SIV-RNA<sup>+</sup> macrophages in the parenchyma, meninges, choroid plexus, dCLN, spleen, and DRG of animals with AIDS and SIVE.

<p>SIV-RNA (red) was detected in the CNS perivascular space, meninges, choroid plexus, and outside of the CNS in the dCLN, spleen, and DRG using RNAscope in situ hybridization. Early (green) SPION were i.c. injected 12-14 dpi and Late (pseudo-colored colored blue) SPION were i.c. injected 30 d...

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Detalles Bibliográficos
Autor Principal: Zoey K. Wallis (17725175) (author)
Outros autores: Cecily C. Midkiff (11083425) (author), Miaoyun Zhao (18996267) (author), Patrick Autissier (93068) (author), Soon Ok Kim (22756434) (author), Addison Q. Amadeck (22756437) (author), Yiwei Wang (403386) (author), Maia Jakubowski (22756440) (author), Tricia H. Burdo (9592101) (author), Andrew D. Miller (328799) (author), Qingsheng Li (515132) (author), Xavier Alvarez (33185) (author), Robert V. Blair (11722847) (author), Kenneth C. Williams (11527354) (author)
Publicado: 2025
Subjects:
Medicine
Microbiology
Neuroscience
Immunology
Infectious Diseases
Plant Biology
Virology
Environmental Sciences not elsewhere classified
sup >+</ sup
simian immunodeficiency virus
peripheral sites including
myeloid cell egress
human immunodeficiency virus
dorsal root ganglia
central nervous system
track macrophage turnover
observed higher numbers
labeled macrophages within
div >< p
cns viral reservoirs
art reduces trafficking
cns </ p
perivascular macrophage reservoir
following art interruption
meningeal macrophages persisted
meningeal macrophages increased
choroid plexus macrophages
art eliminated siv
scattered viral rna
choroid plexus
macrophage traffic
art interruption
meningeal macrophages
trafficking diminished
scattered siv
low numbers
treatment interruption
perivascular macrophages
macrophages trafficked
infected macrophages
viral infection
art treatment
art decreased
preferentially taken
lesser extent
infected macaques
findings support
enabling us
c .)
assess establishment
antiretroviral therapy
administered intracisternal
30 days
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