Integration site analysis and near full-length (NFL) sequencing of p24 + cells. (A) Donut charts displaying the number of HIV integration sites (IS) obtained by ISLA from p24 + cells for four participants in the corresponding Fiebig group. White parts indicate IS detected once and colored parts indicate IS detected more than once. The total number of IS generated by ISLA for each participant is shown in the middle of each donut. (B) Proportion of intact and defective proviral sequences from p24 + cells (n = 47 sequences).

<p>Integration site analysis and near full-length (NFL) sequencing of p24 + cells. (A) Donut charts displaying the number of HIV integration sites (IS) obtained by ISLA from p24 + cells for four participants in the corresponding Fiebig group. White parts indicate IS detected once and colored p...

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Bibliographic Details
Main Author:	Tine Struyve (22683295) (author)
Other Authors:	Marion Pardons (6407921) (author), Jozefien De Clercq (17737815) (author), Liesbet Termote (22683298) (author), Laurens Lambrechts (10532207) (author), Ytse Noppe (22683301) (author), Mathias Lichterfeld (57148) (author), Sofie Rutsaert (10667718) (author), Linos Vandekerckhove (105574) (author)
Published:	2025
Subjects:	Biochemistry Medicine Neuroscience Biotechnology Evolutionary Biology Ecology Cancer Infectious Diseases Plant Biology Virology Computational Biology phorbol myristate acetate integration selection mechanisms xlink "> persistence small reservoir sizes treatment initiation timing clonal expansion contributes art ), irrespective individuals treated shortly reservoir persistence early reservoir persistence clonal expansion started treatment pma ), art initiation viral reservoir treated individuals inducible reservoir individuals treated 1 reservoir suggesting post proviruses integrated progressively enriched one year major barrier longitudinal analysis heterochromatin regions five years chronic cohorts cell compartment antiretroviral therapy already detected
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