(A) Schematic representation of DNA polymerase
<p>β complex. The protein structure includes the Lyase domain (residues 10-87, blue color) and three subdomains: DNA binding (D, residues 90-150, orange color), Catalytic (C, residues 151-260, red color), and Nascent base pairing (N, residues 261-335, green color). These subdomains correspond...
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2025
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| Summary: | <p>β complex. The protein structure includes the Lyase domain (residues 10-87, blue color) and three subdomains: DNA binding (D, residues 90-150, orange color), Catalytic (C, residues 151-260, red color), and Nascent base pairing (N, residues 261-335, green color). These subdomains correspond to the thumb, palm, and fingers subdomains, respectively. The DNA is shown in purple color. The methylated residues (meR83, and meR152) are shown in CPK representation. (<b>B</b>) The time evolution of root mean square deviations (RMSD) of atoms with respect to the initial structure of meR83 (blue), meR152 (red), and meR83,152 (green). (<b>C</b>) Time evolution of RMSD of the backbone atoms of DNA fragment of DNA polymerase β with respect to the initial structure of meR83 (blue), meR152 (red), and meR83,152 (green). (<b>D</b>) Probability distribution of radius of gyration of DNA polymerase β complex: meR83 (blue), meR152 (red), and meR83,152 (green).</p> |
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