Supplementary file 4_Advances in the study of reversing tumor drug resistance by targeting cancer-associated fibroblasts with nanomaterials.docx
<p>Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment (TME) which promote drug resistance by remodeling the extracellular matrix, generating an immunosuppressive microenvironment, and activating metabolic signaling pathways. Nanomaterials provide an effective...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , |
| منشور في: |
2025
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| _version_ | 1851558470665371648 |
|---|---|
| author | Xiaozhuo Gao (22644275) |
| author2 | Lili Sun (162122) Tianming Li (412080) Pengfei Li (290581) Chang Liu (35901) Qiang Li (8118) Yanmei Zhu (3075078) |
| author2_role | author author author author author author |
| author_facet | Xiaozhuo Gao (22644275) Lili Sun (162122) Tianming Li (412080) Pengfei Li (290581) Chang Liu (35901) Qiang Li (8118) Yanmei Zhu (3075078) |
| author_role | author |
| dc.creator.none.fl_str_mv | Xiaozhuo Gao (22644275) Lili Sun (162122) Tianming Li (412080) Pengfei Li (290581) Chang Liu (35901) Qiang Li (8118) Yanmei Zhu (3075078) |
| dc.date.none.fl_str_mv | 2025-11-19T06:26:36Z |
| dc.identifier.none.fl_str_mv | 10.3389/fimmu.2025.1647988.s001 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/Supplementary_file_4_Advances_in_the_study_of_reversing_tumor_drug_resistance_by_targeting_cancer-associated_fibroblasts_with_nanomaterials_docx/30654455 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Genetic Immunology nanomaterials cancer-associated fibroblasts tumor microenvironment tumor drug resistance reverse tumor drug |
| dc.title.none.fl_str_mv | Supplementary file 4_Advances in the study of reversing tumor drug resistance by targeting cancer-associated fibroblasts with nanomaterials.docx |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | <p>Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment (TME) which promote drug resistance by remodeling the extracellular matrix, generating an immunosuppressive microenvironment, and activating metabolic signaling pathways. Nanomaterials provide an effective method for specifically targeting CAF-mediated drug resistance because of their unique targeted delivery capabilities, responsive release characteristics, and multifunctional integration. Here, we describe the mechanisms underlying the role of CAFs in drug resistance. The types of materials used and design principles are described, and examples of the application of nanomaterials for targeting CAFs are provided. Current challenges and future directions of nanomaterials targeting CAFs for reversing tumor drug resistance are also discussed to provide theoretical support for the development of effective nanotherapies aimed at reversing drug resistance in cancer.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_310eaa8ab3ff9b16b51fb7ac7b012d90 |
| identifier_str_mv | 10.3389/fimmu.2025.1647988.s001 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30654455 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Supplementary file 4_Advances in the study of reversing tumor drug resistance by targeting cancer-associated fibroblasts with nanomaterials.docxXiaozhuo Gao (22644275)Lili Sun (162122)Tianming Li (412080)Pengfei Li (290581)Chang Liu (35901)Qiang Li (8118)Yanmei Zhu (3075078)Genetic Immunologynanomaterialscancer-associated fibroblaststumor microenvironmenttumor drug resistancereverse tumor drug<p>Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment (TME) which promote drug resistance by remodeling the extracellular matrix, generating an immunosuppressive microenvironment, and activating metabolic signaling pathways. Nanomaterials provide an effective method for specifically targeting CAF-mediated drug resistance because of their unique targeted delivery capabilities, responsive release characteristics, and multifunctional integration. Here, we describe the mechanisms underlying the role of CAFs in drug resistance. The types of materials used and design principles are described, and examples of the application of nanomaterials for targeting CAFs are provided. Current challenges and future directions of nanomaterials targeting CAFs for reversing tumor drug resistance are also discussed to provide theoretical support for the development of effective nanotherapies aimed at reversing drug resistance in cancer.</p>2025-11-19T06:26:36ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.3389/fimmu.2025.1647988.s001https://figshare.com/articles/dataset/Supplementary_file_4_Advances_in_the_study_of_reversing_tumor_drug_resistance_by_targeting_cancer-associated_fibroblasts_with_nanomaterials_docx/30654455CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/306544552025-11-19T06:26:36Z |
| spellingShingle | Supplementary file 4_Advances in the study of reversing tumor drug resistance by targeting cancer-associated fibroblasts with nanomaterials.docx Xiaozhuo Gao (22644275) Genetic Immunology nanomaterials cancer-associated fibroblasts tumor microenvironment tumor drug resistance reverse tumor drug |
| status_str | publishedVersion |
| title | Supplementary file 4_Advances in the study of reversing tumor drug resistance by targeting cancer-associated fibroblasts with nanomaterials.docx |
| title_full | Supplementary file 4_Advances in the study of reversing tumor drug resistance by targeting cancer-associated fibroblasts with nanomaterials.docx |
| title_fullStr | Supplementary file 4_Advances in the study of reversing tumor drug resistance by targeting cancer-associated fibroblasts with nanomaterials.docx |
| title_full_unstemmed | Supplementary file 4_Advances in the study of reversing tumor drug resistance by targeting cancer-associated fibroblasts with nanomaterials.docx |
| title_short | Supplementary file 4_Advances in the study of reversing tumor drug resistance by targeting cancer-associated fibroblasts with nanomaterials.docx |
| title_sort | Supplementary file 4_Advances in the study of reversing tumor drug resistance by targeting cancer-associated fibroblasts with nanomaterials.docx |
| topic | Genetic Immunology nanomaterials cancer-associated fibroblasts tumor microenvironment tumor drug resistance reverse tumor drug |