Table_1_Case report: Atypical POEMS syndrome without polyneuropathy, complicated by borderline TAFRO syndrome.docx
<p>POEMS syndrome is a complex and rare hematological disease involving multiple physiological systems. According to the currently accepted diagnostic criteria for POEMS syndrome, polyneuropathy is one of the primary mandatory criteria. A patient presented with M protein, Castleman disease (CD...
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2024
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| _version_ | 1852024568324030464 |
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| author | Shuai Tan (783070) |
| author2 | Mingyue Shang (17279695) Yasufumi Masaki (301257) Jing Ni (1887148) Yuwei Da (319130) Jing Sun (141206) Yaofang Cao (20406161) Li Su (71956) Wanling Sun (15325285) |
| author2_role | author author author author author author author author |
| author_facet | Shuai Tan (783070) Mingyue Shang (17279695) Yasufumi Masaki (301257) Jing Ni (1887148) Yuwei Da (319130) Jing Sun (141206) Yaofang Cao (20406161) Li Su (71956) Wanling Sun (15325285) |
| author_role | author |
| dc.creator.none.fl_str_mv | Shuai Tan (783070) Mingyue Shang (17279695) Yasufumi Masaki (301257) Jing Ni (1887148) Yuwei Da (319130) Jing Sun (141206) Yaofang Cao (20406161) Li Su (71956) Wanling Sun (15325285) |
| dc.date.none.fl_str_mv | 2024-12-10T04:04:56Z |
| dc.identifier.none.fl_str_mv | 10.3389/fmed.2024.1445971.s002 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/Table_1_Case_report_Atypical_POEMS_syndrome_without_polyneuropathy_complicated_by_borderline_TAFRO_syndrome_docx/27998171 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Dermatology Emergency Medicine Gastroenterology and Hepatology Geriatrics and Gerontology Intensive Care Medical Genetics (excl. Cancer Genetics) Nephrology and Urology Nuclear Medicine Orthopaedics Otorhinolaryngology Pathology (excl. Oral Pathology) Radiology and Organ Imaging Foetal Development and Medicine Obstetrics and Gynaecology Family Care Primary Health Care Medical and Health Sciences not elsewhere classified POEMS syndrome Castleman disease TAFRO syndrome peripheral neuropathy ASCT |
| dc.title.none.fl_str_mv | Table_1_Case report: Atypical POEMS syndrome without polyneuropathy, complicated by borderline TAFRO syndrome.docx |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | <p>POEMS syndrome is a complex and rare hematological disease involving multiple physiological systems. According to the currently accepted diagnostic criteria for POEMS syndrome, polyneuropathy is one of the primary mandatory criteria. A patient presented with M protein, Castleman disease (CD), elevated vascular endothelial growth factor (VEGF), extravascular volume overload, and endocrinopathy. However, edema of the extremities hindered the diagnosis of polyneuropathy by electromyography (EMG). Eventually, we diagnosed the patient with atypical POEMS syndrome without polyneuropathy. The case also exhibited features consistent with TAFRO syndrome, such as anasarca, thrombocytopenia, and renal insufficiency. This underscores the need to emphasize that TAFRO syndrome is principally a systemic inflammatory disorder. Timely diagnosis and treatment with dexamethasone, followed by several sessions of lenalidomide and dexamethasone (Rd) regimen chemotherapy, resulted in complete remission (CR), and was followed by autologous stem cell transplantation (ASCT). This case offers valuable insights into the diagnosis and treatment of POEMS syndrome, which may prompt a reconsideration of the diagnostic criteria for this syndrome.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_3253ee4bbc52b3bfbc7bf2c19a9bfe9d |
| identifier_str_mv | 10.3389/fmed.2024.1445971.s002 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/27998171 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Table_1_Case report: Atypical POEMS syndrome without polyneuropathy, complicated by borderline TAFRO syndrome.docxShuai Tan (783070)Mingyue Shang (17279695)Yasufumi Masaki (301257)Jing Ni (1887148)Yuwei Da (319130)Jing Sun (141206)Yaofang Cao (20406161)Li Su (71956)Wanling Sun (15325285)DermatologyEmergency MedicineGastroenterology and HepatologyGeriatrics and GerontologyIntensive CareMedical Genetics (excl. Cancer Genetics)Nephrology and UrologyNuclear MedicineOrthopaedicsOtorhinolaryngologyPathology (excl. Oral Pathology)Radiology and Organ ImagingFoetal Development and MedicineObstetrics and GynaecologyFamily CarePrimary Health CareMedical and Health Sciences not elsewhere classifiedPOEMS syndromeCastleman diseaseTAFRO syndromeperipheral neuropathyASCT<p>POEMS syndrome is a complex and rare hematological disease involving multiple physiological systems. According to the currently accepted diagnostic criteria for POEMS syndrome, polyneuropathy is one of the primary mandatory criteria. A patient presented with M protein, Castleman disease (CD), elevated vascular endothelial growth factor (VEGF), extravascular volume overload, and endocrinopathy. However, edema of the extremities hindered the diagnosis of polyneuropathy by electromyography (EMG). Eventually, we diagnosed the patient with atypical POEMS syndrome without polyneuropathy. The case also exhibited features consistent with TAFRO syndrome, such as anasarca, thrombocytopenia, and renal insufficiency. This underscores the need to emphasize that TAFRO syndrome is principally a systemic inflammatory disorder. Timely diagnosis and treatment with dexamethasone, followed by several sessions of lenalidomide and dexamethasone (Rd) regimen chemotherapy, resulted in complete remission (CR), and was followed by autologous stem cell transplantation (ASCT). This case offers valuable insights into the diagnosis and treatment of POEMS syndrome, which may prompt a reconsideration of the diagnostic criteria for this syndrome.</p>2024-12-10T04:04:56ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.3389/fmed.2024.1445971.s002https://figshare.com/articles/dataset/Table_1_Case_report_Atypical_POEMS_syndrome_without_polyneuropathy_complicated_by_borderline_TAFRO_syndrome_docx/27998171CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/279981712024-12-10T04:04:56Z |
| spellingShingle | Table_1_Case report: Atypical POEMS syndrome without polyneuropathy, complicated by borderline TAFRO syndrome.docx Shuai Tan (783070) Dermatology Emergency Medicine Gastroenterology and Hepatology Geriatrics and Gerontology Intensive Care Medical Genetics (excl. Cancer Genetics) Nephrology and Urology Nuclear Medicine Orthopaedics Otorhinolaryngology Pathology (excl. Oral Pathology) Radiology and Organ Imaging Foetal Development and Medicine Obstetrics and Gynaecology Family Care Primary Health Care Medical and Health Sciences not elsewhere classified POEMS syndrome Castleman disease TAFRO syndrome peripheral neuropathy ASCT |
| status_str | publishedVersion |
| title | Table_1_Case report: Atypical POEMS syndrome without polyneuropathy, complicated by borderline TAFRO syndrome.docx |
| title_full | Table_1_Case report: Atypical POEMS syndrome without polyneuropathy, complicated by borderline TAFRO syndrome.docx |
| title_fullStr | Table_1_Case report: Atypical POEMS syndrome without polyneuropathy, complicated by borderline TAFRO syndrome.docx |
| title_full_unstemmed | Table_1_Case report: Atypical POEMS syndrome without polyneuropathy, complicated by borderline TAFRO syndrome.docx |
| title_short | Table_1_Case report: Atypical POEMS syndrome without polyneuropathy, complicated by borderline TAFRO syndrome.docx |
| title_sort | Table_1_Case report: Atypical POEMS syndrome without polyneuropathy, complicated by borderline TAFRO syndrome.docx |
| topic | Dermatology Emergency Medicine Gastroenterology and Hepatology Geriatrics and Gerontology Intensive Care Medical Genetics (excl. Cancer Genetics) Nephrology and Urology Nuclear Medicine Orthopaedics Otorhinolaryngology Pathology (excl. Oral Pathology) Radiology and Organ Imaging Foetal Development and Medicine Obstetrics and Gynaecology Family Care Primary Health Care Medical and Health Sciences not elsewhere classified POEMS syndrome Castleman disease TAFRO syndrome peripheral neuropathy ASCT |