Results of MC simulations of VO and agonist infusion.

<p>Top panels show normalized growth in CellArea for 100 representative simulations (gray lines), with terminal values indicated by black circles; adjacent boxplots reflect the mean, CI50, and CI90 of terminal values for 1000 simulations of a) Untreated VO, c) ISO infusion, and e) AngII infusi...

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Bibliographic Details
Main Author:	Johane H. Bracamonte (12883844) (author)
Other Authors:	Lionel Watkins (21101254) (author), Betty Pat (15336130) (author), Louis J. Dell’Italia (8770514) (author), Jeffrey J. Saucerman (8131425) (author), Jeffrey W. Holmes (6087089) (author)
Published:	2025
Subjects:	Medicine Biological Sciences not elsewhere classified Information Systems not elsewhere classified treat heart failure provide significant recovery myocardial tissue stretch mitral valve repair increased myocyte strain calibrated model predicts based network model intracellular signaling network compensatory neurohormonal responses alters mechanical loading ventricular volume overload experimental volume overload cardiac hypertrophy driven mechanical loading overload hypertrophy volume overload neurohormonal response hypertrophic signaling expected responses cardiac function mostly driven eccentric hypertrophy driven primarily treated according time course questions remain quantitative predictions promising approach potential interventions optimal timing operatively despite observation contrasts multiple studies left ventricle known structure knowledge gap integrate information initial increase including infusion hypertrophic process experimental vo current guidelines common perception combine data better understanding better personalize bayesian approach 70 studies 43 studies
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Results of MC simulations of VO and agonist infusion.

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