Oligomeric Changes Regulate Flavin Transfer in Two-Component FMN Reductases Involved in Sulfur Metabolism

The FMN reductases (SsuE and MsuE of the alkanesulfonate monooxygenase systems) supply reduced flavin to their partner monooxygenases for the desulfonation of alkanesulfonates. Flavin reductases that comprise two-component systems must be able to regulate both flavin reduction and transfer. One mech...

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Bibliographic Details
Main Author:	Chioma H. Aloh (16913999) (author)
Other Authors:	Tonya N. Zeczycki (1752880) (author), Holly R. Ellis (1450228) (author)
Published:	2023
Subjects:	Biophysics Biochemistry Medicine Microbiology Physiology Biotechnology Computational Biology Biological Sciences not elsewhere classified slower exchange along similar overall structures component systems must analytical ultracentrifugation studies alkanesulfonate monooxygenase systems supply reduced flavin providing reduced flavin different structural shifts multiple monooxygenase enzymes similar oligomeric shift single tetrameric state fmn complex slowed distinct tetramer showed oligomeric state oligomeric shift fmn complex flavin reduction flavin reductases distinct processes different roles oligomeric states msue showed tetramer equilibrium sulfur metabolism significant increase region around partner monooxygenases melting temperature increased stability fmn reductases fast tetramer enzymes play conformers formed bound enzyme
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Oligomeric Changes Regulate Flavin Transfer in Two-Component FMN Reductases Involved in Sulfur Metabolism

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