A835D increases SHC014-CoV S binding to HsACE2.

(a) Genome-normalized amounts of scVSV particles bearing WT or A835D SHC014-CoV spike were diluted with serial 3-fold dilutions and loaded on an ELISA plate precoated with soluble HsACE2 and detected with a spike-specific mAb followed by an anti-human H...

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Bibliographic Details
Main Author:	Alexandra L. Tse (20235212) (author)
Other Authors:	Cory M. Acreman (20235215) (author), Inna Ricardo-Lax (4543948) (author), Jacob Berrigan (11052951) (author), Gorka Lasso (215085) (author), Toheeb Balogun (20235218) (author), Fiona L. Kearns (11841216) (author), Lorenzo Casalino (2850134) (author), Georgia L. McClain (20235221) (author), Amartya Mudry Chandran (20235224) (author), Charlotte Lemeunier (20235227) (author), Rommie E. Amaro (82566) (author), Charles M. Rice (9110743) (author), Rohit K. Jangra (6639905) (author), Jason S. McLellan (8816639) (author), Kartik Chandran (134142) (author), Emily Happy Miller (10652108) (author)
Published:	2024
Subjects:	Microbiology Cell Biology Neuroscience Evolutionary Biology Immunology Cancer Mental Health Infectious Diseases Virology Environmental Sciences not elsewhere classified zoonotic risks posed xlink "> understanding s2 fusion peptide cell entry mechanisms like bat cov divergent bat covs enhanced receptor binding cell entry binding domain bat covs bat coronaviruses viral entry cellular receptor enhanced spike virus bearing terminal domain successful recovery spike receptor serial passage second substitution proximal region pandemic preparedness offs inherent novel substitution fppr substitution fppr ). fitness trade coronavirus contexts bearing spikes
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A835D increases SHC014-CoV S binding to <i>HsACE2</i>.

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