Normal tone detection but impaired discrimination in Fmr1 KO rats.

(A) Schematic of Go/No-Go operant tone detection task. 9 wildtype (black) and 10 Fmr1 KO (red) rats were trained to report the detection of any tone burst (HIT), with failure to do so resulting in a MISS. On 30% of trials no sound was presented (catch t...

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Bibliographic Details
Main Author:	D. Walker Gauthier (21637726) (author)
Other Authors:	Noelle James (4245589) (author), Benjamin D. Auerbach (21637729) (author)
Published:	2025
Subjects:	Sociology Science Policy Mental Health Biological Sciences not elsewhere classified vivo electrophysiological recordings potential mechanistic locus leading inherited cause fragile x syndrome autism spectrum disorders atypical sensory processing altered spectral processing abnormal perceptual integration fine feature discrimination disrupted language comprehension cortical tuning width broader frequency tuning sound processing difficulties auditory processing alterations auditory coding impairments auditory behavioral phenotypes signal detection threshold fxs individuals present div >< p common phenotype observed cortical physiological differences ko rats using ko rat model rat model frequency discrimination auditory cortical speech comprehension cortical hyperexcitability sound sensitivity sound encoding auditory processes auditory issues auditory hypersensitivity auditory domain auditory cortex tightly linked stimulus bandwidth source segregation shown previously rodent models preserve signal noise ratios neuronal hyperactivity inferior colliculus fundamental aspect fmr1 </ findings indicate decoder performance could contribute collicular neurons
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Normal tone detection but impaired discrimination in <i>Fmr1</i> KO rats.

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