Data Sheet 1_REST corepressor 2 contributes to the cell proliferation of endometrial cancer.docx
Background<p>Uterine corpus endometrial cancer (UCEC) is a prevalent gynecological malignancy. REST corepressor 2 (RCOR2), a nuclear transcription co-repressor, has been implicated in various cellular processes. However, its regulatory role in UCEC progression remains unclear.</p>Methods...
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2025
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| _version_ | 1852017255008698368 |
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| author | Qingjuan Zhu (22130035) |
| author2 | Xin Yang (104842) Yuchun Lv (10331372) |
| author2_role | author author |
| author_facet | Qingjuan Zhu (22130035) Xin Yang (104842) Yuchun Lv (10331372) |
| author_role | author |
| dc.creator.none.fl_str_mv | Qingjuan Zhu (22130035) Xin Yang (104842) Yuchun Lv (10331372) |
| dc.date.none.fl_str_mv | 2025-08-27T04:10:54Z |
| dc.identifier.none.fl_str_mv | 10.3389/fonc.2025.1539263.s001 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/Data_Sheet_1_REST_corepressor_2_contributes_to_the_cell_proliferation_of_endometrial_cancer_docx/29993155 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Oncology and Carcinogenesis not elsewhere classified RCOR2 endometrial cancer UCEC viability proliferation |
| dc.title.none.fl_str_mv | Data Sheet 1_REST corepressor 2 contributes to the cell proliferation of endometrial cancer.docx |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | Background<p>Uterine corpus endometrial cancer (UCEC) is a prevalent gynecological malignancy. REST corepressor 2 (RCOR2), a nuclear transcription co-repressor, has been implicated in various cellular processes. However, its regulatory role in UCEC progression remains unclear.</p>Methods<p>RCOR2 expression levels were analyzed in UCEC tissues and cell lines using qPCR, Western blotting. Functional assays, including CCK8 and colony formation assays, were used to assess the impact of RCOR2 knockdown or overexpression on UCEC cell viability and proliferation.</p>Results<p>RCOR2 expression was significantly elevated in UCEC tissues compared to adjacent normal tissues. High RCOR2 expression correlated with advanced clinical stage, high histologic grade, and lymph node metastasis. ROC analysis indicated strong diagnostic value. RCOR2 expression showed a positive correlation with proliferation-related genes MKI67, CCND1, and PCNA. Functional assays revealed that RCOR2 knockdown suppressed, while overexpression promoted, proliferation of endometrial cancer cells. These effects were validated by CCK8 and colony formation assays, as well as changes in mRNA and protein levels of MKI67, CCND1, and PCNA, supporting RCOR2’s role in regulating UCEC cell proliferation.</p>Conclusions<p>These findings suggest that RCOR2 promotes endometrial cancer progression by enhancing tumor cell proliferation and may serve as a potential diagnostic and therapeutic target in UCEC.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_387afd9e2a92ea8a85ff3fbdf726ce95 |
| identifier_str_mv | 10.3389/fonc.2025.1539263.s001 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/29993155 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Data Sheet 1_REST corepressor 2 contributes to the cell proliferation of endometrial cancer.docxQingjuan Zhu (22130035)Xin Yang (104842)Yuchun Lv (10331372)Oncology and Carcinogenesis not elsewhere classifiedRCOR2endometrial cancerUCECviabilityproliferationBackground<p>Uterine corpus endometrial cancer (UCEC) is a prevalent gynecological malignancy. REST corepressor 2 (RCOR2), a nuclear transcription co-repressor, has been implicated in various cellular processes. However, its regulatory role in UCEC progression remains unclear.</p>Methods<p>RCOR2 expression levels were analyzed in UCEC tissues and cell lines using qPCR, Western blotting. Functional assays, including CCK8 and colony formation assays, were used to assess the impact of RCOR2 knockdown or overexpression on UCEC cell viability and proliferation.</p>Results<p>RCOR2 expression was significantly elevated in UCEC tissues compared to adjacent normal tissues. High RCOR2 expression correlated with advanced clinical stage, high histologic grade, and lymph node metastasis. ROC analysis indicated strong diagnostic value. RCOR2 expression showed a positive correlation with proliferation-related genes MKI67, CCND1, and PCNA. Functional assays revealed that RCOR2 knockdown suppressed, while overexpression promoted, proliferation of endometrial cancer cells. These effects were validated by CCK8 and colony formation assays, as well as changes in mRNA and protein levels of MKI67, CCND1, and PCNA, supporting RCOR2’s role in regulating UCEC cell proliferation.</p>Conclusions<p>These findings suggest that RCOR2 promotes endometrial cancer progression by enhancing tumor cell proliferation and may serve as a potential diagnostic and therapeutic target in UCEC.</p>2025-08-27T04:10:54ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.3389/fonc.2025.1539263.s001https://figshare.com/articles/dataset/Data_Sheet_1_REST_corepressor_2_contributes_to_the_cell_proliferation_of_endometrial_cancer_docx/29993155CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/299931552025-08-27T04:10:54Z |
| spellingShingle | Data Sheet 1_REST corepressor 2 contributes to the cell proliferation of endometrial cancer.docx Qingjuan Zhu (22130035) Oncology and Carcinogenesis not elsewhere classified RCOR2 endometrial cancer UCEC viability proliferation |
| status_str | publishedVersion |
| title | Data Sheet 1_REST corepressor 2 contributes to the cell proliferation of endometrial cancer.docx |
| title_full | Data Sheet 1_REST corepressor 2 contributes to the cell proliferation of endometrial cancer.docx |
| title_fullStr | Data Sheet 1_REST corepressor 2 contributes to the cell proliferation of endometrial cancer.docx |
| title_full_unstemmed | Data Sheet 1_REST corepressor 2 contributes to the cell proliferation of endometrial cancer.docx |
| title_short | Data Sheet 1_REST corepressor 2 contributes to the cell proliferation of endometrial cancer.docx |
| title_sort | Data Sheet 1_REST corepressor 2 contributes to the cell proliferation of endometrial cancer.docx |
| topic | Oncology and Carcinogenesis not elsewhere classified RCOR2 endometrial cancer UCEC viability proliferation |