Dataset.rar.
<div><p>Background</p><p>Hyperlipidemia is a major modifiable risk factor for cardiovascular disease, and emerging evidence suggests a critical role of the gut microbiota in lipid metabolism. The Dietary Index for Gut Microbiota (DI-GM) is a novel tool designed to capture the...
সংরক্ষণ করুন:
| প্রধান লেখক: | |
|---|---|
| অন্যান্য লেখক: | |
| প্রকাশিত: |
2025
|
| বিষয়গুলি: | |
| ট্যাগগুলো: |
ট্যাগ যুক্ত করুন
কোনো ট্যাগ নেই, প্রথমজন হিসাবে ট্যাগ করুন!
|
| _version_ | 1849927643232731136 |
|---|---|
| author | Wenjing Wang (181404) |
| author2 | Weinan Jiang (8346891) |
| author2_role | author |
| author_facet | Wenjing Wang (181404) Weinan Jiang (8346891) |
| author_role | author |
| dc.creator.none.fl_str_mv | Wenjing Wang (181404) Weinan Jiang (8346891) |
| dc.date.none.fl_str_mv | 2025-11-24T18:25:44Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0337398.s002 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/Dataset_rar_/30696762 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biochemistry Cell Biology Biotechnology Ecology Immunology Cancer Science Policy Infectious Diseases Chemical Sciences not elsewhere classified weighted logistic regression novel tool designed lowering medication use emerging evidence suggests dose &# 8211 735 &# 8211 2010 &# 8211 relevant dietary components relevant dietary assessment oriented dietary patterns habitual dietary patterns mediation analysis using mediation analysis showed hour recall data reflecting 14 microbiota nutrition examination survey lipid management strategies systemic inflammation underscores xlink "> microbiota xlink "> hyperlipidemia xlink "> dietary index systemic inflammation partial mediation analyzed data systemic immune inflammation index gut microbiota supportive potential supportive diets spline models significantly associated response relationship nhanes ). national health mediating role lower odds lipid metabolism inversely associated integrating microbiome highest vs fully adjusted findings highlight critical role cardiovascular disease assess associations 883 ). 2020 cycles |
| dc.title.none.fl_str_mv | Dataset.rar. |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | <div><p>Background</p><p>Hyperlipidemia is a major modifiable risk factor for cardiovascular disease, and emerging evidence suggests a critical role of the gut microbiota in lipid metabolism. The Dietary Index for Gut Microbiota (DI-GM) is a novel tool designed to capture the microbiota-supportive potential of habitual dietary patterns, yet its association with lipid abnormalities remains underexplored in large populations.</p><p>Methods</p><p>We analyzed data from 21,352 adults in the 2010–2020 cycles of the National Health and Nutrition Examination Survey (NHANES). The DI-GM, reflecting 14 microbiota-relevant dietary components, was derived from 24-hour recall data. Hyperlipidemia was defined using standard lipid thresholds or lipid-lowering medication use. Survey-weighted logistic regression, restricted cubic spline analysis, and mediation analysis using the systemic immune-inflammation index (SII) were performed to assess associations and potential mechanisms.</p><p>Results</p><p>Higher DI-GM scores were significantly associated with lower odds of hyperlipidemia (fully adjusted OR for highest vs. lowest category = 0.806; 95% CI: 0.735–0.883). A dose–response relationship was confirmed in spline models. Mediation analysis showed that systemic inflammation, as quantified by SII, accounted for 17.8% of the observed association, suggesting an immunometabolic pathway linking diet and lipid status.</p><p>Conclusion</p><p>Microbiota-oriented dietary patterns, as captured by the DI-GM, are inversely associated with hyperlipidemia in U.S. adults. These findings highlight the value of integrating microbiome-relevant dietary assessment into lipid management strategies. Partial mediation by systemic inflammation underscores a potential mechanistic link warranting further investigation through longitudinal and interventional studies.</p></div> |
| eu_rights_str_mv | openAccess |
| id | Manara_391a845f6542eacab6812f6538618d53 |
| identifier_str_mv | 10.1371/journal.pone.0337398.s002 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30696762 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Dataset.rar.Wenjing Wang (181404)Weinan Jiang (8346891)BiochemistryCell BiologyBiotechnologyEcologyImmunologyCancerScience PolicyInfectious DiseasesChemical Sciences not elsewhere classifiedweighted logistic regressionnovel tool designedlowering medication useemerging evidence suggestsdose &# 8211735 &# 82112010 &# 8211relevant dietary componentsrelevant dietary assessmentoriented dietary patternshabitual dietary patternsmediation analysis usingmediation analysis showedhour recall datareflecting 14 microbiotanutrition examination surveylipid management strategiessystemic inflammation underscoresxlink "> microbiotaxlink "> hyperlipidemiaxlink ">dietary indexsystemic inflammationpartial mediationanalyzed datasystemic immuneinflammation indexgut microbiotasupportive potentialsupportive dietsspline modelssignificantly associatedresponse relationshipnhanes ).national healthmediating rolelower oddslipid metabolisminversely associatedintegrating microbiomehighest vsfully adjustedfindings highlightcritical rolecardiovascular diseaseassess associations883 ).2020 cycles<div><p>Background</p><p>Hyperlipidemia is a major modifiable risk factor for cardiovascular disease, and emerging evidence suggests a critical role of the gut microbiota in lipid metabolism. The Dietary Index for Gut Microbiota (DI-GM) is a novel tool designed to capture the microbiota-supportive potential of habitual dietary patterns, yet its association with lipid abnormalities remains underexplored in large populations.</p><p>Methods</p><p>We analyzed data from 21,352 adults in the 2010–2020 cycles of the National Health and Nutrition Examination Survey (NHANES). The DI-GM, reflecting 14 microbiota-relevant dietary components, was derived from 24-hour recall data. Hyperlipidemia was defined using standard lipid thresholds or lipid-lowering medication use. Survey-weighted logistic regression, restricted cubic spline analysis, and mediation analysis using the systemic immune-inflammation index (SII) were performed to assess associations and potential mechanisms.</p><p>Results</p><p>Higher DI-GM scores were significantly associated with lower odds of hyperlipidemia (fully adjusted OR for highest vs. lowest category = 0.806; 95% CI: 0.735–0.883). A dose–response relationship was confirmed in spline models. Mediation analysis showed that systemic inflammation, as quantified by SII, accounted for 17.8% of the observed association, suggesting an immunometabolic pathway linking diet and lipid status.</p><p>Conclusion</p><p>Microbiota-oriented dietary patterns, as captured by the DI-GM, are inversely associated with hyperlipidemia in U.S. adults. These findings highlight the value of integrating microbiome-relevant dietary assessment into lipid management strategies. Partial mediation by systemic inflammation underscores a potential mechanistic link warranting further investigation through longitudinal and interventional studies.</p></div>2025-11-24T18:25:44ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.1371/journal.pone.0337398.s002https://figshare.com/articles/dataset/Dataset_rar_/30696762CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/306967622025-11-24T18:25:44Z |
| spellingShingle | Dataset.rar. Wenjing Wang (181404) Biochemistry Cell Biology Biotechnology Ecology Immunology Cancer Science Policy Infectious Diseases Chemical Sciences not elsewhere classified weighted logistic regression novel tool designed lowering medication use emerging evidence suggests dose &# 8211 735 &# 8211 2010 &# 8211 relevant dietary components relevant dietary assessment oriented dietary patterns habitual dietary patterns mediation analysis using mediation analysis showed hour recall data reflecting 14 microbiota nutrition examination survey lipid management strategies systemic inflammation underscores xlink "> microbiota xlink "> hyperlipidemia xlink "> dietary index systemic inflammation partial mediation analyzed data systemic immune inflammation index gut microbiota supportive potential supportive diets spline models significantly associated response relationship nhanes ). national health mediating role lower odds lipid metabolism inversely associated integrating microbiome highest vs fully adjusted findings highlight critical role cardiovascular disease assess associations 883 ). 2020 cycles |
| status_str | publishedVersion |
| title | Dataset.rar. |
| title_full | Dataset.rar. |
| title_fullStr | Dataset.rar. |
| title_full_unstemmed | Dataset.rar. |
| title_short | Dataset.rar. |
| title_sort | Dataset.rar. |
| topic | Biochemistry Cell Biology Biotechnology Ecology Immunology Cancer Science Policy Infectious Diseases Chemical Sciences not elsewhere classified weighted logistic regression novel tool designed lowering medication use emerging evidence suggests dose &# 8211 735 &# 8211 2010 &# 8211 relevant dietary components relevant dietary assessment oriented dietary patterns habitual dietary patterns mediation analysis using mediation analysis showed hour recall data reflecting 14 microbiota nutrition examination survey lipid management strategies systemic inflammation underscores xlink "> microbiota xlink "> hyperlipidemia xlink "> dietary index systemic inflammation partial mediation analyzed data systemic immune inflammation index gut microbiota supportive potential supportive diets spline models significantly associated response relationship nhanes ). national health mediating role lower odds lipid metabolism inversely associated integrating microbiome highest vs fully adjusted findings highlight critical role cardiovascular disease assess associations 883 ). 2020 cycles |