Table 1_VPS35 D620N mutation impairs neurogenesis and promotes ferroptosis in Parkinson’s disease by using molecular docking, molecular dynamic simulation, and cellular model.docx

Table 1_VPS35 D620N mutation impairs neurogenesis and promotes ferroptosis in Parkinson’s disease by using molecular docking, molecular dynamic simulation, and cellular model.docx

Backgroud<p>VPS35, a core component of the retromer complex, has been closely associated with neurodegenerative disorders, particularly Parkinson’s disease (PD). The VPS35 D620N mutation has been identified as a pathogenic variant in familial PD. However, the precise mechanisms by which VPS35...

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Príomhchruthaitheoir: Mei Jiang (192549) (author)
Rannpháirtithe: Xu Deng (1688152) (author), Zijie Qiu (3367016) (author), Yuan Fu (1373553) (author), Zixiong Qiu (22679216) (author), Jiankai Zhang (4502368) (author), Hongxia Fu (423266) (author), Jie Li (15030) (author), Yao Luo (1636354) (author), Xiaojun Cui (14526278) (author)
Foilsithe / Cruthaithe: 2025
Ábhair:
Neuroscience
VPS35 D620N
Parkinson’s disease
neurogenesis
cell death
ferroptosis
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