Loss of MAP4K4 expression affects apoptosis during the process of neutrophil differentiation.

<p>(A) UMAP plot of the neutrophil co-expression network. Each node represents a single gene, and edges represent co-expression links between genes and module hub genes. Point size is scaled by eigengene-based connectivity (kME). Nodes are colored by co-expression module assignment. The top fi...

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Main Author:	Guihua Wang (286390) (author)
Other Authors:	Dan Zhang (51283) (author), Zhifeng He (5136524) (author), Bin Mao (2001418) (author), Xiao Hu (233579) (author), Li Chen (5749) (author), Qingxin Yang (5561867) (author), Zhen Zhou (184390) (author), Yating Zhang (218669) (author), Kepan Linghu (20890196) (author), Chao Tang (10925) (author), Zijie Xu (10648835) (author), Defu Liu (1701892) (author), Junwei Song (4060921) (author), Huiying Wang (807020) (author), Yishan Lin (9159326) (author), Ruihan Li (6611660) (author), Jing-Wen Lin (1734628) (author), Lu Chen (75170) (author)
Published:	2025
Subjects:	Cell Biology Genetics Molecular Biology Physiology Immunology Developmental Biology Hematology Computational Biology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Information Systems not elsewhere classified novel regulatory mechanism mice induced neutropenia hematopoietic stem cells activated protein kinase robust prediction model molecular regulators involved identify neutrophil regulators identified pipeline leads div >< p proteins involved model training learning pipeline work presents utilized positive silico </ short lifespan random forest physiological characteristics phosphorylation level phosphorylating apoptosis pathological relatedness neutrophil differentiation neural network macrophage progenitor identifying mitogen gmp ), gene knockout gene conservation continuous replenishment cell apoptosis bone marrow 4 (<
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Loss of MAP4K4 expression affects apoptosis during the process of neutrophil differentiation.

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