Electronic Structure and Redox of the Antidepressants Venlafaxine and Desvenlafaxine

Electronic Structure and Redox of the Antidepressants Venlafaxine and Desvenlafaxine

Venlafaxine and its primary metabolite desvenlafaxine are antidepressants that block presynaptic reuptake of serotonin and norepinephrine in the brain. Electroanalytical and computational analyses were performed to evaluate the electrochemical characterization of these drugs through measurements usi...

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Bibliographic Details
Main Author: Jhon Kennedy Alves Pereira (22681627) (author)
Other Authors: Eufrásia de Sousa Pereira (22681630) (author), Bárbara Júlia Gonçalves Dutra (22681633) (author), Isaac Yves Lopes de Macêdo (22681636) (author), Arthur Saldanha Guimarães (22681639) (author), Bruno Junior Neves (5960789) (author), Eric de Souza Gil (6303956) (author), Freddy Fernandes Guimarães (6293438) (author)
Published: 2025
Subjects:
Biophysics
Biochemistry
Pharmacology
Space Science
Chemical Sciences not elsewhere classified
molecular charge distribution
effective therapeutic agents
block presynaptic reuptake
primary metabolite desvenlafaxine
td – dft
dft calculations provided
dependent electrochemical behaviors
desvenlafaxine venlafaxine
thermodynamic stability
results showed
protonated states
orbital profiles
measurements using
may pave
findings presented
electronic structure
electronic properties
electrochemical data
electrochemical characterization
critical role
computational insights
computational analyses
alkaline ph
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