AKT regulates UGCG expression via epigenomic alterations.

(A) A schematic diagram showing AKT-mediated phosphorylation of DNMT1 leading to hypomethylation of CpG islands that further enhances UGCG expression. (B) Immunoblot showing alteration in phosphorylation of DNMT1 by pan-phospho-ser antibody in MCF-7_RIC...

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Main Author:	Mohammad Nafees Ansari (22232505) (author)
Other Authors:	Somesh K. Jha (20722073) (author), Ali Khan (568900) (author), Kajal Rajput (11403230) (author), Nishant Pandey (5578880) (author), Dolly Jain (11403227) (author), Rajeshwari Tripathi (22232508) (author), Nihal Medatwal (4251403) (author), Pankaj Sharma (58141) (author), Sudeshna Datta (3643081) (author), Animesh Kar (4583296) (author), Trishna Pani (22232511) (author), Sk Asif Ali (22232514) (author), Kaushavi Cholke (19669386) (author), Kajal Rana (11403212) (author), Valiya P. Snijesh (22232517) (author), Geetashree Mukherjee (264708) (author), Suryanarayana V. S. Deo (22232520) (author), Soumen Basak (1681390) (author), Ashutosh Mishra (231926) (author), Jyothi S. Prabhu (3173547) (author), Arnab Mukhopadhyay (5645819) (author), Avinash Bajaj (1910212) (author), Ujjaini Dasgupta (7483922) (author)
Published:	2025
Subjects:	Biochemistry Cell Biology Genetics Molecular Biology Developmental Biology Cancer Hematology Plant Biology Computational Biology Chemical Sciences not elsewhere classified dna methyltransferase 1 human cell culture cancer cell proliferation key regulatory circuit ganglioside metabolic pathways div >< p promoting ganglioside biosynthesis known akt substrates egfr signaling pathway cell signaling ganglioside biosynthesis regulatory subunit less known specific mcf mouse models metabric datasets mammalian cells kdm5a ), histone demethylase established roles epigenetic mechanisms crucial components 474 cells
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AKT regulates UGCG expression via epigenomic alterations.

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