MultiCRISPR-EGA: Optimizing Guide RNA Array Design for Multiplexed CRISPR Using the Elitist Genetic Algorithm

Multiplexed CRISPR design, which allows for the concurrent and efficient editing of multiple genomic sites, is a powerful tool for complex genetic modifications. However, designing effective multiplexed guide RNA (gRNA) arrays remains challenging due to the exponential increase in potential gRNA arr...

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Bibliographic Details
Main Author:	Yangyu Zhang (4609117) (author)
Other Authors:	Guanlin Chen (20758526) (author), Ce Liang (8307540) (author), Bin Yang (103252) (author), Xin Lei (1622128) (author), Tao Chen (75911) (author), Huaiguang Jiang (20758529) (author), Wei Xiong (58411) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Genetics Molecular Biology Evolutionary Biology Space Science Biological Sciences not elsewhere classified Information Systems not elsewhere classified thus higher efficacy multiple genomic sites intelligent optimization algorithms gui provides real graphical user interface elitist genetic algorithm design optimized single complex genetic modifications effective genome editing multiplexed crispr using various crispr crispr interference tool aims synthetic biology stable grnas significant impact prolonged activity powerful tool mfe ), exponential increase efficient editing computational experiments cas systems
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MultiCRISPR-EGA: Optimizing Guide RNA Array Design for Multiplexed CRISPR Using the Elitist Genetic Algorithm

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