A. <i>T. gondii</i> gene group changes throughout the time course, expressed as log<sub>2</sub>(fold change) relative to pre-infection tachyzoites (t = 0). Grey area depicts the 95% confidence interval. n value refers to number of genes detected in each group. B. Gene set enrichment plot for most enriched terms from <i>T. gondii</i> transcriptome features at 15 min to 120 min. Five most significant terms are displayed for each database. C and D. Transcriptional profiles of top five upregulated and downregulated <i>T. gondii</i> transcription factors, respectively.
<p>A. <i>T. gondii</i> gene group changes throughout the time course, expressed as log<sub>2</sub>(fold change) relative to pre-infection tachyzoites (t = 0). Grey area depicts the 95% confidence interval. n value refers to number of genes detected in each group. B. Gen...
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2025
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| _version_ | 1849927643743387648 |
|---|---|
| author | Dominykas Murza (22676289) |
| author2 | Filip Lastovka (22676292) George Wood (7488866) Matthew P. Brember (12780473) Oliver Chan (22676295) James W. Ajioka (9255) Betty Y. W. Chung (22676298) |
| author2_role | author author author author author author |
| author_facet | Dominykas Murza (22676289) Filip Lastovka (22676292) George Wood (7488866) Matthew P. Brember (12780473) Oliver Chan (22676295) James W. Ajioka (9255) Betty Y. W. Chung (22676298) |
| author_role | author |
| dc.creator.none.fl_str_mv | Dominykas Murza (22676289) Filip Lastovka (22676292) George Wood (7488866) Matthew P. Brember (12780473) Oliver Chan (22676295) James W. Ajioka (9255) Betty Y. W. Chung (22676298) |
| dc.date.none.fl_str_mv | 2025-11-24T18:22:18Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0336849.g003 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/A_i_T_gondii_i_gene_group_changes_throughout_the_time_course_expressed_as_log_sub_2_sub_fold_change_relative_to_pre-infection_tachyzoites_t_0_Grey_area_depicts_the_95_confidence_interval_n_value_refers_to_number_of_genes_detected_in_each_gr/30696408 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Microbiology Cell Biology Immunology Developmental Biology Science Policy Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Physical Sciences not elsewhere classified resolved transcriptomic profiling leveraging inactivated parasites initial triggers shaping immune system ’ immune suppressors dominates even behavioural changes div >< p strategic transcriptional shift live infection — earliest transcriptional shifts determining infection outcomes general immune activation toxoplasma gondii </ gondii </ transcriptional level infection model delayed activation using time study unveils secreted proteins pivotal role parasite secures mouse macrophage master manipulator macrophage response increased suppressor hormone disruption growth capacity first responders first line findings reveal early upregulation early increase disentangled responses delayed strategy apicomplexan parasite active invasion 7 -< 60 minutes |
| dc.title.none.fl_str_mv | A. <i>T. gondii</i> gene group changes throughout the time course, expressed as log<sub>2</sub>(fold change) relative to pre-infection tachyzoites (t = 0). Grey area depicts the 95% confidence interval. n value refers to number of genes detected in each group. B. Gene set enrichment plot for most enriched terms from <i>T. gondii</i> transcriptome features at 15 min to 120 min. Five most significant terms are displayed for each database. C and D. Transcriptional profiles of top five upregulated and downregulated <i>T. gondii</i> transcription factors, respectively. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>A. <i>T. gondii</i> gene group changes throughout the time course, expressed as log<sub>2</sub>(fold change) relative to pre-infection tachyzoites (t = 0). Grey area depicts the 95% confidence interval. n value refers to number of genes detected in each group. B. Gene set enrichment plot for most enriched terms from <i>T. gondii</i> transcriptome features at 15 min to 120 min. Five most significant terms are displayed for each database. C and D. Transcriptional profiles of top five upregulated and downregulated <i>T. gondii</i> transcription factors, respectively.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_3da131161f7b268e0436bdbf921c9dac |
| identifier_str_mv | 10.1371/journal.pone.0336849.g003 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30696408 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | A. <i>T. gondii</i> gene group changes throughout the time course, expressed as log<sub>2</sub>(fold change) relative to pre-infection tachyzoites (t = 0). Grey area depicts the 95% confidence interval. n value refers to number of genes detected in each group. B. Gene set enrichment plot for most enriched terms from <i>T. gondii</i> transcriptome features at 15 min to 120 min. Five most significant terms are displayed for each database. C and D. Transcriptional profiles of top five upregulated and downregulated <i>T. gondii</i> transcription factors, respectively.Dominykas Murza (22676289)Filip Lastovka (22676292)George Wood (7488866)Matthew P. Brember (12780473)Oliver Chan (22676295)James W. Ajioka (9255)Betty Y. W. Chung (22676298)MicrobiologyCell BiologyImmunologyDevelopmental BiologyScience PolicyInfectious DiseasesEnvironmental Sciences not elsewhere classifiedBiological Sciences not elsewhere classifiedPhysical Sciences not elsewhere classifiedresolved transcriptomic profilingleveraging inactivated parasitesinitial triggers shapingimmune system ’immune suppressors dominateseven behavioural changesdiv >< pstrategic transcriptional shiftlive infection —earliest transcriptional shiftsdetermining infection outcomesgeneral immune activationtoxoplasma gondii </gondii </transcriptional levelinfection modeldelayed activationusing timestudy unveilssecreted proteinspivotal roleparasite securesmouse macrophagemaster manipulatormacrophage responseincreased suppressorhormone disruptiongrowth capacityfirst respondersfirst linefindings revealearly upregulationearly increasedisentangled responsesdelayed strategyapicomplexan parasiteactive invasion7 -<60 minutes<p>A. <i>T. gondii</i> gene group changes throughout the time course, expressed as log<sub>2</sub>(fold change) relative to pre-infection tachyzoites (t = 0). Grey area depicts the 95% confidence interval. n value refers to number of genes detected in each group. B. Gene set enrichment plot for most enriched terms from <i>T. gondii</i> transcriptome features at 15 min to 120 min. Five most significant terms are displayed for each database. C and D. Transcriptional profiles of top five upregulated and downregulated <i>T. gondii</i> transcription factors, respectively.</p>2025-11-24T18:22:18ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pone.0336849.g003https://figshare.com/articles/figure/A_i_T_gondii_i_gene_group_changes_throughout_the_time_course_expressed_as_log_sub_2_sub_fold_change_relative_to_pre-infection_tachyzoites_t_0_Grey_area_depicts_the_95_confidence_interval_n_value_refers_to_number_of_genes_detected_in_each_gr/30696408CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/306964082025-11-24T18:22:18Z |
| spellingShingle | A. <i>T. gondii</i> gene group changes throughout the time course, expressed as log<sub>2</sub>(fold change) relative to pre-infection tachyzoites (t = 0). Grey area depicts the 95% confidence interval. n value refers to number of genes detected in each group. B. Gene set enrichment plot for most enriched terms from <i>T. gondii</i> transcriptome features at 15 min to 120 min. Five most significant terms are displayed for each database. C and D. Transcriptional profiles of top five upregulated and downregulated <i>T. gondii</i> transcription factors, respectively. Dominykas Murza (22676289) Microbiology Cell Biology Immunology Developmental Biology Science Policy Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Physical Sciences not elsewhere classified resolved transcriptomic profiling leveraging inactivated parasites initial triggers shaping immune system ’ immune suppressors dominates even behavioural changes div >< p strategic transcriptional shift live infection — earliest transcriptional shifts determining infection outcomes general immune activation toxoplasma gondii </ gondii </ transcriptional level infection model delayed activation using time study unveils secreted proteins pivotal role parasite secures mouse macrophage master manipulator macrophage response increased suppressor hormone disruption growth capacity first responders first line findings reveal early upregulation early increase disentangled responses delayed strategy apicomplexan parasite active invasion 7 -< 60 minutes |
| status_str | publishedVersion |
| title | A. <i>T. gondii</i> gene group changes throughout the time course, expressed as log<sub>2</sub>(fold change) relative to pre-infection tachyzoites (t = 0). Grey area depicts the 95% confidence interval. n value refers to number of genes detected in each group. B. Gene set enrichment plot for most enriched terms from <i>T. gondii</i> transcriptome features at 15 min to 120 min. Five most significant terms are displayed for each database. C and D. Transcriptional profiles of top five upregulated and downregulated <i>T. gondii</i> transcription factors, respectively. |
| title_full | A. <i>T. gondii</i> gene group changes throughout the time course, expressed as log<sub>2</sub>(fold change) relative to pre-infection tachyzoites (t = 0). Grey area depicts the 95% confidence interval. n value refers to number of genes detected in each group. B. Gene set enrichment plot for most enriched terms from <i>T. gondii</i> transcriptome features at 15 min to 120 min. Five most significant terms are displayed for each database. C and D. Transcriptional profiles of top five upregulated and downregulated <i>T. gondii</i> transcription factors, respectively. |
| title_fullStr | A. <i>T. gondii</i> gene group changes throughout the time course, expressed as log<sub>2</sub>(fold change) relative to pre-infection tachyzoites (t = 0). Grey area depicts the 95% confidence interval. n value refers to number of genes detected in each group. B. Gene set enrichment plot for most enriched terms from <i>T. gondii</i> transcriptome features at 15 min to 120 min. Five most significant terms are displayed for each database. C and D. Transcriptional profiles of top five upregulated and downregulated <i>T. gondii</i> transcription factors, respectively. |
| title_full_unstemmed | A. <i>T. gondii</i> gene group changes throughout the time course, expressed as log<sub>2</sub>(fold change) relative to pre-infection tachyzoites (t = 0). Grey area depicts the 95% confidence interval. n value refers to number of genes detected in each group. B. Gene set enrichment plot for most enriched terms from <i>T. gondii</i> transcriptome features at 15 min to 120 min. Five most significant terms are displayed for each database. C and D. Transcriptional profiles of top five upregulated and downregulated <i>T. gondii</i> transcription factors, respectively. |
| title_short | A. <i>T. gondii</i> gene group changes throughout the time course, expressed as log<sub>2</sub>(fold change) relative to pre-infection tachyzoites (t = 0). Grey area depicts the 95% confidence interval. n value refers to number of genes detected in each group. B. Gene set enrichment plot for most enriched terms from <i>T. gondii</i> transcriptome features at 15 min to 120 min. Five most significant terms are displayed for each database. C and D. Transcriptional profiles of top five upregulated and downregulated <i>T. gondii</i> transcription factors, respectively. |
| title_sort | A. <i>T. gondii</i> gene group changes throughout the time course, expressed as log<sub>2</sub>(fold change) relative to pre-infection tachyzoites (t = 0). Grey area depicts the 95% confidence interval. n value refers to number of genes detected in each group. B. Gene set enrichment plot for most enriched terms from <i>T. gondii</i> transcriptome features at 15 min to 120 min. Five most significant terms are displayed for each database. C and D. Transcriptional profiles of top five upregulated and downregulated <i>T. gondii</i> transcription factors, respectively. |
| topic | Microbiology Cell Biology Immunology Developmental Biology Science Policy Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Physical Sciences not elsewhere classified resolved transcriptomic profiling leveraging inactivated parasites initial triggers shaping immune system ’ immune suppressors dominates even behavioural changes div >< p strategic transcriptional shift live infection — earliest transcriptional shifts determining infection outcomes general immune activation toxoplasma gondii </ gondii </ transcriptional level infection model delayed activation using time study unveils secreted proteins pivotal role parasite secures mouse macrophage master manipulator macrophage response increased suppressor hormone disruption growth capacity first responders first line findings reveal early upregulation early increase disentangled responses delayed strategy apicomplexan parasite active invasion 7 -< 60 minutes |