CPAF-deficient strain exhibits reduced progeny yield.

CPAF-deficient strain exhibits reduced progeny yield.

<p>(A) The cryptic plasmid copy number and chlamydial HSP60 levels in the cell supernatant of CPAF-deficient strain (L2-17/mCherry) (MOI 1)-infected HeLa-229 cells were measured, compared to those in CPAF-supplemented strain (L2-17/CPAF) (MOI 1)-infected cells. Statistical analysis was perform...

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Main Author: Wentao Chen (626428) (author)
Other Authors: Xin Su (338394) (author), Yuying Pan (14800243) (author), Han Zhou (109068) (author), Yidan Gao (14620035) (author), Xuemei Wang (39992) (author), Lijuan Jiang (501223) (author), Lihong Zeng (15594179) (author), Qingqing Xu (465549) (author), Xueying Yu (605947) (author), Xiaona Yin (9023591) (author), Zhanqin Feng (3721183) (author), Bao Zhang (186933) (author), Wei Zhao (14321) (author), Yaohua Xue (3150252) (author), Lingli Tang (436791) (author), Heping Zheng (538162) (author)
Published: 2025
Subjects:
Biophysics
Microbiology
Cell Biology
Immunology
Cancer
Infectious Diseases
Computational Biology
Biological Sciences not elsewhere classified
vitamin e reduces
trends toward attenuation
prevalent bacterial agent
low genital tract
like activity factor
host protein slc7a11
host cells plays
deficient strain fails
conserved survival strategies
sexually transmitted infections
chlamydia trachomatis ,</
cpaf ), resulting
new infections
chlamydia </
significant threat
reproductive health
process involves
orchestrated lysis
novel mechanism
lipid peroxidation
inhibiting ferroptosis
induce ferroptosis
glutathione depletion
crucial role
chlamydial protease
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Summary:<p>(A) The cryptic plasmid copy number and chlamydial HSP60 levels in the cell supernatant of CPAF-deficient strain (L2-17/mCherry) (MOI 1)-infected HeLa-229 cells were measured, compared to those in CPAF-supplemented strain (L2-17/CPAF) (MOI 1)-infected cells. Statistical analysis was performed using a Student’s t-test (n=3). (B) The <i>ompA</i> copy number in the total culture (supernatant and monolayer) of CPAF-deficient strain (L2-17/mCherry) (MOI 1)- or CPAF-supplemented strain (L2-17/CPAF) (MOI 1)-infected HeLa-229 cells was determined over a time course. Statistical analysis was performed using a two-way ANOVA (n=3). <i>P</i> values are indicated as follows: *, <i>P</i> < 0.05; **, <i>P</i> < 0.01; ***, <i>P</i> < 0.001.</p> <p>(TIF)</p>

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