Behavioral, cardiac, and brain-activity responses to EBL with machine-learning-based functional clustering.
<p><b>(A)</b> Representative depiction of zebrafish larvae tail movement, <b>(B)</b> Tail-swing area metric (area per movement frequency); <b>(C)</b> Heart rate (beats per minute); <b>(D)</b> T-score BAM at 0.088% EBL (color scale encodes T-score...
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2025
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| Summary: | <p><b>(A)</b> Representative depiction of zebrafish larvae tail movement, <b>(B)</b> Tail-swing area metric (area per movement frequency); <b>(C)</b> Heart rate (beats per minute); <b>(D)</b> T-score BAM at 0.088% EBL (color scale encodes T-score magnitude, with orange representing increased and blue indicating lower activity), <b>(E)</b> Radar plot of similarity between the EBL phenotype and reference drugs classes derived from standardized feature vectors. EBL (green line) shows high similarity to antitumor, uric acid-lowering, and hypoglycemic drugs. Concentric circles indicate similarity from low (center) to high (periphery). Data are mean ± SD. Two-tailed unpaired t-tests were used for behavior and heart rate; <i>P</i> < 0.05(*) was considered significant (ns, not significant). Similarity scores in panel E reflect clustering outputs and do not denote statistical significance.</p> |
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