Behavioral, cardiac, and brain-activity responses to EBL with machine-learning-based functional clustering.
<p><b>(A)</b> Representative depiction of zebrafish larvae tail movement, <b>(B)</b> Tail-swing area metric (area per movement frequency); <b>(C)</b> Heart rate (beats per minute); <b>(D)</b> T-score BAM at 0.088% EBL (color scale encodes T-score...
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2025
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| _version_ | 1849927643715076096 |
|---|---|
| author | Zhuangbin Zheng (22676304) |
| author2 | Fanlei Ran (7352957) Lushan Liang (22676307) Yiqian Zhang (752795) Xianwen Li (3910537) Liqun Zhang (115900) Lijun Bi (121470) |
| author2_role | author author author author author author |
| author_facet | Zhuangbin Zheng (22676304) Fanlei Ran (7352957) Lushan Liang (22676307) Yiqian Zhang (752795) Xianwen Li (3910537) Liqun Zhang (115900) Lijun Bi (121470) |
| author_role | author |
| dc.creator.none.fl_str_mv | Zhuangbin Zheng (22676304) Fanlei Ran (7352957) Lushan Liang (22676307) Yiqian Zhang (752795) Xianwen Li (3910537) Liqun Zhang (115900) Lijun Bi (121470) |
| dc.date.none.fl_str_mv | 2025-11-24T18:22:41Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0336479.g006 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Behavioral_cardiac_and_brain-activity_responses_to_EBL_with_machine-learning-based_functional_clustering_/30696453 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Pharmacology Biotechnology Evolutionary Biology Immunology Infectious Diseases Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified total antioxidant capacity recent studies indicate prior preparation work pollutant degradation owing larva zebrafish (< high reducing power danio rerio </ ebl ), reference transiently generated e div >< p 1 mv ), biomedical effects study level effects ebl ’ biomedical potential biomedical application widely studied uric acid reduction potential precluding storage ph 13 orp 47 new potentials hypoglycemic drugs hydrated electrons findings motivate biological investigation adverse concentration |
| dc.title.none.fl_str_mv | Behavioral, cardiac, and brain-activity responses to EBL with machine-learning-based functional clustering. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p><b>(A)</b> Representative depiction of zebrafish larvae tail movement, <b>(B)</b> Tail-swing area metric (area per movement frequency); <b>(C)</b> Heart rate (beats per minute); <b>(D)</b> T-score BAM at 0.088% EBL (color scale encodes T-score magnitude, with orange representing increased and blue indicating lower activity), <b>(E)</b> Radar plot of similarity between the EBL phenotype and reference drugs classes derived from standardized feature vectors. EBL (green line) shows high similarity to antitumor, uric acid-lowering, and hypoglycemic drugs. Concentric circles indicate similarity from low (center) to high (periphery). Data are mean ± SD. Two-tailed unpaired t-tests were used for behavior and heart rate; <i>P</i> < 0.05(*) was considered significant (ns, not significant). Similarity scores in panel E reflect clustering outputs and do not denote statistical significance.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_3e215951ebcb11652865bf7d663e22a9 |
| identifier_str_mv | 10.1371/journal.pone.0336479.g006 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30696453 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Behavioral, cardiac, and brain-activity responses to EBL with machine-learning-based functional clustering.Zhuangbin Zheng (22676304)Fanlei Ran (7352957)Lushan Liang (22676307)Yiqian Zhang (752795)Xianwen Li (3910537)Liqun Zhang (115900)Lijun Bi (121470)PharmacologyBiotechnologyEvolutionary BiologyImmunologyInfectious DiseasesBiological Sciences not elsewhere classifiedChemical Sciences not elsewhere classifiedtotal antioxidant capacityrecent studies indicateprior preparation workpollutant degradation owinglarva zebrafish (<high reducing powerdanio rerio </ebl ), referencetransiently generated ediv >< p1 mv ),biomedical effects studylevel effectsebl ’biomedical potentialbiomedical applicationwidely studieduric acidreduction potentialprecluding storageph 13orp 47new potentialshypoglycemic drugshydrated electronsfindings motivatebiological investigationadverse concentration<p><b>(A)</b> Representative depiction of zebrafish larvae tail movement, <b>(B)</b> Tail-swing area metric (area per movement frequency); <b>(C)</b> Heart rate (beats per minute); <b>(D)</b> T-score BAM at 0.088% EBL (color scale encodes T-score magnitude, with orange representing increased and blue indicating lower activity), <b>(E)</b> Radar plot of similarity between the EBL phenotype and reference drugs classes derived from standardized feature vectors. EBL (green line) shows high similarity to antitumor, uric acid-lowering, and hypoglycemic drugs. Concentric circles indicate similarity from low (center) to high (periphery). Data are mean ± SD. Two-tailed unpaired t-tests were used for behavior and heart rate; <i>P</i> < 0.05(*) was considered significant (ns, not significant). Similarity scores in panel E reflect clustering outputs and do not denote statistical significance.</p>2025-11-24T18:22:41ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pone.0336479.g006https://figshare.com/articles/figure/Behavioral_cardiac_and_brain-activity_responses_to_EBL_with_machine-learning-based_functional_clustering_/30696453CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/306964532025-11-24T18:22:41Z |
| spellingShingle | Behavioral, cardiac, and brain-activity responses to EBL with machine-learning-based functional clustering. Zhuangbin Zheng (22676304) Pharmacology Biotechnology Evolutionary Biology Immunology Infectious Diseases Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified total antioxidant capacity recent studies indicate prior preparation work pollutant degradation owing larva zebrafish (< high reducing power danio rerio </ ebl ), reference transiently generated e div >< p 1 mv ), biomedical effects study level effects ebl ’ biomedical potential biomedical application widely studied uric acid reduction potential precluding storage ph 13 orp 47 new potentials hypoglycemic drugs hydrated electrons findings motivate biological investigation adverse concentration |
| status_str | publishedVersion |
| title | Behavioral, cardiac, and brain-activity responses to EBL with machine-learning-based functional clustering. |
| title_full | Behavioral, cardiac, and brain-activity responses to EBL with machine-learning-based functional clustering. |
| title_fullStr | Behavioral, cardiac, and brain-activity responses to EBL with machine-learning-based functional clustering. |
| title_full_unstemmed | Behavioral, cardiac, and brain-activity responses to EBL with machine-learning-based functional clustering. |
| title_short | Behavioral, cardiac, and brain-activity responses to EBL with machine-learning-based functional clustering. |
| title_sort | Behavioral, cardiac, and brain-activity responses to EBL with machine-learning-based functional clustering. |
| topic | Pharmacology Biotechnology Evolutionary Biology Immunology Infectious Diseases Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified total antioxidant capacity recent studies indicate prior preparation work pollutant degradation owing larva zebrafish (< high reducing power danio rerio </ ebl ), reference transiently generated e div >< p 1 mv ), biomedical effects study level effects ebl ’ biomedical potential biomedical application widely studied uric acid reduction potential precluding storage ph 13 orp 47 new potentials hypoglycemic drugs hydrated electrons findings motivate biological investigation adverse concentration |