Behavioral, cardiac, and brain-activity responses to EBL with machine-learning-based functional clustering.

(A) Representative depiction of zebrafish larvae tail movement, (B) Tail-swing area metric (area per movement frequency); (C) Heart rate (beats per minute); (D) T-score BAM at 0.088% EBL (color scale encodes T-score...

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Tác giả chính:	Zhuangbin Zheng (22676304) (author)
Tác giả khác:	Fanlei Ran (7352957) (author), Lushan Liang (22676307) (author), Yiqian Zhang (752795) (author), Xianwen Li (3910537) (author), Liqun Zhang (115900) (author), Lijun Bi (121470) (author)
Được phát hành:	2025
Những chủ đề:	Pharmacology Biotechnology Evolutionary Biology Immunology Infectious Diseases Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified total antioxidant capacity recent studies indicate prior preparation work pollutant degradation owing larva zebrafish (< high reducing power danio rerio </ ebl ), reference transiently generated e div >< p 1 mv ), biomedical effects study level effects ebl ’ biomedical potential biomedical application widely studied uric acid reduction potential precluding storage ph 13 orp 47 new potentials hypoglycemic drugs hydrated electrons findings motivate biological investigation adverse concentration
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author	Zhuangbin Zheng (22676304)
author2	Fanlei Ran (7352957) Lushan Liang (22676307) Yiqian Zhang (752795) Xianwen Li (3910537) Liqun Zhang (115900) Lijun Bi (121470)
author2_role	author author author author author author
author_facet	Zhuangbin Zheng (22676304) Fanlei Ran (7352957) Lushan Liang (22676307) Yiqian Zhang (752795) Xianwen Li (3910537) Liqun Zhang (115900) Lijun Bi (121470)
author_role	author
dc.creator.none.fl_str_mv	Zhuangbin Zheng (22676304) Fanlei Ran (7352957) Lushan Liang (22676307) Yiqian Zhang (752795) Xianwen Li (3910537) Liqun Zhang (115900) Lijun Bi (121470)
dc.date.none.fl_str_mv	2025-11-24T18:22:41Z
dc.identifier.none.fl_str_mv	10.1371/journal.pone.0336479.g006
dc.relation.none.fl_str_mv	https://figshare.com/articles/figure/Behavioral_cardiac_and_brain-activity_responses_to_EBL_with_machine-learning-based_functional_clustering_/30696453
dc.rights.none.fl_str_mv	CC BY 4.0 info:eu-repo/semantics/openAccess
dc.subject.none.fl_str_mv	Pharmacology Biotechnology Evolutionary Biology Immunology Infectious Diseases Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified total antioxidant capacity recent studies indicate prior preparation work pollutant degradation owing larva zebrafish (< high reducing power danio rerio </ ebl ), reference transiently generated e div >< p 1 mv ), biomedical effects study level effects ebl ’ biomedical potential biomedical application widely studied uric acid reduction potential precluding storage ph 13 orp 47 new potentials hypoglycemic drugs hydrated electrons findings motivate biological investigation adverse concentration
dc.title.none.fl_str_mv	Behavioral, cardiac, and brain-activity responses to EBL with machine-learning-based functional clustering.
dc.type.none.fl_str_mv	Image Figure info:eu-repo/semantics/publishedVersion image
description	<p><b>(A)</b> Representative depiction of zebrafish larvae tail movement, <b>(B)</b> Tail-swing area metric (area per movement frequency); <b>(C)</b> Heart rate (beats per minute); <b>(D)</b> T-score BAM at 0.088% EBL (color scale encodes T-score magnitude, with orange representing increased and blue indicating lower activity), <b>(E)</b> Radar plot of similarity between the EBL phenotype and reference drugs classes derived from standardized feature vectors. EBL (green line) shows high similarity to antitumor, uric acid-lowering, and hypoglycemic drugs. Concentric circles indicate similarity from low (center) to high (periphery). Data are mean ± SD. Two-tailed unpaired t-tests were used for behavior and heart rate; <i>P</i> < 0.05(*) was considered significant (ns, not significant). Similarity scores in panel E reflect clustering outputs and do not denote statistical significance.</p>
eu_rights_str_mv	openAccess
id	Manara_3e215951ebcb11652865bf7d663e22a9
identifier_str_mv	10.1371/journal.pone.0336479.g006
network_acronym_str	Manara
network_name_str	ManaraRepo
oai_identifier_str	oai:figshare.com:article/30696453
publishDate	2025
repository.mail.fl_str_mv
repository.name.fl_str_mv
repository_id_str
rights_invalid_str_mv	CC BY 4.0
spelling	Behavioral, cardiac, and brain-activity responses to EBL with machine-learning-based functional clustering.Zhuangbin Zheng (22676304)Fanlei Ran (7352957)Lushan Liang (22676307)Yiqian Zhang (752795)Xianwen Li (3910537)Liqun Zhang (115900)Lijun Bi (121470)PharmacologyBiotechnologyEvolutionary BiologyImmunologyInfectious DiseasesBiological Sciences not elsewhere classifiedChemical Sciences not elsewhere classifiedtotal antioxidant capacityrecent studies indicateprior preparation workpollutant degradation owinglarva zebrafish (<high reducing powerdanio rerio </ebl ), referencetransiently generated ediv >< p1 mv ),biomedical effects studylevel effectsebl ’biomedical potentialbiomedical applicationwidely studieduric acidreduction potentialprecluding storageph 13orp 47new potentialshypoglycemic drugshydrated electronsfindings motivatebiological investigationadverse concentration<p><b>(A)</b> Representative depiction of zebrafish larvae tail movement, <b>(B)</b> Tail-swing area metric (area per movement frequency); <b>(C)</b> Heart rate (beats per minute); <b>(D)</b> T-score BAM at 0.088% EBL (color scale encodes T-score magnitude, with orange representing increased and blue indicating lower activity), <b>(E)</b> Radar plot of similarity between the EBL phenotype and reference drugs classes derived from standardized feature vectors. EBL (green line) shows high similarity to antitumor, uric acid-lowering, and hypoglycemic drugs. Concentric circles indicate similarity from low (center) to high (periphery). Data are mean ± SD. Two-tailed unpaired t-tests were used for behavior and heart rate; <i>P</i> < 0.05(*) was considered significant (ns, not significant). Similarity scores in panel E reflect clustering outputs and do not denote statistical significance.</p>2025-11-24T18:22:41ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pone.0336479.g006https://figshare.com/articles/figure/Behavioral_cardiac_and_brain-activity_responses_to_EBL_with_machine-learning-based_functional_clustering_/30696453CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/306964532025-11-24T18:22:41Z
spellingShingle	Behavioral, cardiac, and brain-activity responses to EBL with machine-learning-based functional clustering. Zhuangbin Zheng (22676304) Pharmacology Biotechnology Evolutionary Biology Immunology Infectious Diseases Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified total antioxidant capacity recent studies indicate prior preparation work pollutant degradation owing larva zebrafish (< high reducing power danio rerio </ ebl ), reference transiently generated e div >< p 1 mv ), biomedical effects study level effects ebl ’ biomedical potential biomedical application widely studied uric acid reduction potential precluding storage ph 13 orp 47 new potentials hypoglycemic drugs hydrated electrons findings motivate biological investigation adverse concentration
status_str	publishedVersion
title	Behavioral, cardiac, and brain-activity responses to EBL with machine-learning-based functional clustering.
title_full	Behavioral, cardiac, and brain-activity responses to EBL with machine-learning-based functional clustering.
title_fullStr	Behavioral, cardiac, and brain-activity responses to EBL with machine-learning-based functional clustering.
title_full_unstemmed	Behavioral, cardiac, and brain-activity responses to EBL with machine-learning-based functional clustering.
title_short	Behavioral, cardiac, and brain-activity responses to EBL with machine-learning-based functional clustering.
title_sort	Behavioral, cardiac, and brain-activity responses to EBL with machine-learning-based functional clustering.
topic	Pharmacology Biotechnology Evolutionary Biology Immunology Infectious Diseases Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified total antioxidant capacity recent studies indicate prior preparation work pollutant degradation owing larva zebrafish (< high reducing power danio rerio </ ebl ), reference transiently generated e div >< p 1 mv ), biomedical effects study level effects ebl ’ biomedical potential biomedical application widely studied uric acid reduction potential precluding storage ph 13 orp 47 new potentials hypoglycemic drugs hydrated electrons findings motivate biological investigation adverse concentration

Behavioral, cardiac, and brain-activity responses to EBL with machine-learning-based functional clustering.

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