Regio- and Enantioselective Palladium-Catalyzed (4 + 2) Silacycloaddition of Unsymmetrical Internal Alkynes with Racemic Benzosilacyclobutenes

Silicon-stereogenic architectures are valuable in organosilicon chemistry and medicinal chemistry, but their enantioselective synthesis via silicon-centered chirality transfer remains a challenge. In contrast to well-studied chirality-at-carbon chemistry, the construction of silicon-stereogenic cent...

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Bibliographic Details
Main Author:	Xing-Ben Wang (21514819) (author)
Other Authors:	Jun-Jie Guo (176349) (author), Cheng Chen (136164) (author), Jia-Wei Si (21514822) (author), Zheng Xu (162992) (author), Zhi-Yuan Zhao (7357058) (author), Zhuangzhi Shi (1429201) (author), Fuk Yee Kwong (1470919) (author), Li-Wen Xu (572954) (author)
Published:	2025
Subjects:	Biochemistry Molecular Biology Biotechnology Immunology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified unsymmetrical internal alkynes derived phosphoramidite ligand challenging topic due racemic substrates corroborate broad substrate scope robust strategy called limited synthetic strategy demonstrating broad applicability kinetic resolution process stereogenic organosilicon compounds catalyzed enantioselective ring racemic benzosilacyclobutenes silicon racemic substrate racemic benzosilacyclobutenes kinetic resolution organosilicon chemistry kinetic studies stereogenic centers stereogenic benzo stereogenic architectures studied chirality silin derivatives medicinal chemistry high chemoselectivity good enantioselectivity ester groups enantioselective palladium chiral taddol carbon chemistry
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Regio- and Enantioselective Palladium-Catalyzed (4 + 2) Silacycloaddition of Unsymmetrical Internal Alkynes with Racemic Benzosilacyclobutenes

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