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Rg over time.

<div><p>Cyclin-dependent kinases 4 and 6 (CDK4/6) are crucial regulators of cell cycle progression and represent important therapeutic targets in breast cancer. This study employs a comprehensive computational approach to identify novel CDK4/6 inhibitors from marine natural products. We...

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Bibliographic Details
Main Author: Abhijit Debnath (17497764) (author)
Other Authors: Rupa Mazumder (12184129) (author), Anil Kumar Singh (7551270) (author), Rajesh Kumar Singh (8690151) (author)
Published: 2025
Subjects:
Biochemistry
Pharmacology
Inorganic Chemistry
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Information Systems not elsewhere classified
marine natural products
indicating better compatibility
exhibiting lower rmsd
comprehensive computational approach
comprehensive 500 nanosecond
cell cycle progression
autodock vina 1
25 exhibited non
dependent kinases 4
dependent kinase 4
rigorous filtering based
based virtual screening
div >< p
6 active site
344 passed drug
identify novel cdk4
autodocktools 4
vitro </
utilized structure
toxicity profiles
toxic profiles
study employs
structural stability
six top
rmsf values
pains filters
pains filter
novel cyclin
mnp library
initial hit
highest potency
cytotoxic effects
crucial regulators
cmnpd11585 showing
cmnpd database
breast cancer
analysis revealed
adme properties
6 inhibitors
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