C2CD3 is crucial for the localization of the LDR and DISCO complexes.

C2CD3 is crucial for the localization of the LDR and DISCO complexes.

<p><b>(A)</b> Expanded centrioles from control (siCTRL) and C2CD3-depleted (siC2CD3) cells stained for C2CD3 (green) and tubulin (magenta). Centriole length is significantly reduced in siC2CD3 (<i>n</i> = 61, 200 ± 48 nm) compared to siCTRL (<i>n</i> = 63, 4...

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Main Author: Eloïse Bertiaux (5309927) (author)
Other Authors: Vincent Louvel (10291256) (author), Caitlyn L. McCafferty (4669267) (author), Hugo van den Hoek (22813456) (author), Umut Batman (13113614) (author), Souradip Mukherjee (22813459) (author), Lorène Bournonville (10291253) (author), Olivier Mercey (713210) (author), Isabelle Méan (11411492) (author), Ricardo D. Righetto (22813462) (author), Adrian Müller (22813465) (author), Philippe Van der Stappen (22813468) (author), Garrison Buss (22813471) (author), Jean Daraspe (5574758) (author), Christel Genoud (66232) (author), Tim Stearns (106556) (author), Benjamin D. Engel (22813474) (author), Virginie Hamel (10291262) (author), Paul Guichard (10291259) (author)
Published: 2025
Subjects:
Biophysics
Biochemistry
Microbiology
Cell Biology
Molecular Biology
Biotechnology
Evolutionary Biology
Infectious Diseases
precise molecular role
fold organization within
intricate &# 8220
xlink "> centrioles
radially symmetric 9
molecular hub connecting
luminal ring structure
c2cd3 localizes close
c2cd3 depletion disrupts
centriole &# 8217
distal microtubule cap
appendages </ p
distal appendage assembly
&# 8221
shorter centrioles
architectural hub
appendage defects
distal lumen
distal end
distal centriole
like structure
protein c2cd3
c2cd3 forms
c2cd3 adopts
triplet microtubules
terminal region
polarized microtubule
orofaciodigital syndrome
ofd1 ),
mutations linked
mouse tissues
human cells
extends radially
electron tomography
disco complex
cilia formation
centriole interior
centriolar lumen
based structures
also destabilizes
27 nodes
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