C2CD3 is crucial for the localization of the LDR and DISCO complexes.

(A) Expanded centrioles from control (siCTRL) and C2CD3-depleted (siC2CD3) cells stained for C2CD3 (green) and tubulin (magenta). Centriole length is significantly reduced in siC2CD3 (n = 61, 200 ± 48 nm) compared to siCTRL (n = 63, 4...

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Main Author:	Eloïse Bertiaux (5309927) (author)
Other Authors:	Vincent Louvel (10291256) (author), Caitlyn L. McCafferty (4669267) (author), Hugo van den Hoek (22813456) (author), Umut Batman (13113614) (author), Souradip Mukherjee (22813459) (author), Lorène Bournonville (10291253) (author), Olivier Mercey (713210) (author), Isabelle Méan (11411492) (author), Ricardo D. Righetto (22813462) (author), Adrian Müller (22813465) (author), Philippe Van der Stappen (22813468) (author), Garrison Buss (22813471) (author), Jean Daraspe (5574758) (author), Christel Genoud (66232) (author), Tim Stearns (106556) (author), Benjamin D. Engel (22813474) (author), Virginie Hamel (10291262) (author), Paul Guichard (10291259) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Microbiology Cell Biology Molecular Biology Biotechnology Evolutionary Biology Infectious Diseases precise molecular role fold organization within intricate &# 8220 xlink "> centrioles radially symmetric 9 molecular hub connecting luminal ring structure c2cd3 localizes close c2cd3 depletion disrupts centriole &# 8217 distal microtubule cap appendages </ p distal appendage assembly &# 8221 shorter centrioles architectural hub appendage defects distal lumen distal end distal centriole like structure protein c2cd3 c2cd3 forms c2cd3 adopts triplet microtubules terminal region polarized microtubule orofaciodigital syndrome ofd1 ), mutations linked mouse tissues human cells extends radially electron tomography disco complex cilia formation centriole interior centriolar lumen based structures also destabilizes 27 nodes
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C2CD3 is crucial for the localization of the LDR and DISCO complexes.

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