Supplementary Figure S1 from A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma

<p>Validation cohort, patient flow diagram. Patient enrollment and final inclusion of FFPE tissue samples in this study is shown. n = 3 patients were excluded from enrollment for reasons listed. The validation cohort comprised paired tissue samples from a total of n = 38 patients. Detailed cha...

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Autor principal:	Sied Kebir (15048732) (author)
Outros Autores:	Vivien Ullrich (15048735) (author), Pia Berger (15048738) (author), Celia Dobersalske (15048741) (author), Sarah Langer (15048744) (author), Laurèl Rauschenbach (15048747) (author), Daniel Trageser (15048750) (author), Andreas Till (15048753) (author), Franziska K. Lorbeer (15048756) (author), Anja Wieland (15048759) (author), Timo Wilhelm-Buchstab (15048762) (author), Ashar Ahmad (15048765) (author), Holger Fröhlich (8724576) (author), Igor Cima (15048768) (author), Shruthi Prasad (15048771) (author), Johann Matschke (15048774) (author), Verena Jendrossek (15048777) (author), Marc Remke (14962619) (author), Barbara M. Grüner (14947089) (author), Alexander Roesch (15048780) (author), Jens T. Siveke (11780911) (author), Christel Herold-Mende (15047946) (author), Tobias Blau (15048783) (author), Kathy Keyvani (15048786) (author), Frank K.H. van Landeghem (15048789) (author), Torsten Pietsch (15048792) (author), Jörg Felsberg (15048795) (author), Guido Reifenberger (12335398) (author), Michael Weller (15037908) (author), Ulrich Sure (15048798) (author), Oliver Brüstle (15048801) (author), Matthias Simon (15048804) (author), Martin Glas (15048807) (author), Björn Scheffler (15048810) (author)
Publicado em:	2025
Assuntos:	Cancer Therapeutic Research and Development Clinical Research and Trials CNS Cancers Gliomas, Glioblastomas Drug Targets Precision Medicine
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author	Sied Kebir (15048732)
author2	Vivien Ullrich (15048735) Pia Berger (15048738) Celia Dobersalske (15048741) Sarah Langer (15048744) Laurèl Rauschenbach (15048747) Daniel Trageser (15048750) Andreas Till (15048753) Franziska K. Lorbeer (15048756) Anja Wieland (15048759) Timo Wilhelm-Buchstab (15048762) Ashar Ahmad (15048765) Holger Fröhlich (8724576) Igor Cima (15048768) Shruthi Prasad (15048771) Johann Matschke (15048774) Verena Jendrossek (15048777) Marc Remke (14962619) Barbara M. Grüner (14947089) Alexander Roesch (15048780) Jens T. Siveke (11780911) Christel Herold-Mende (15047946) Tobias Blau (15048783) Kathy Keyvani (15048786) Frank K.H. van Landeghem (15048789) Torsten Pietsch (15048792) Jörg Felsberg (15048795) Guido Reifenberger (12335398) Michael Weller (15037908) Ulrich Sure (15048798) Oliver Brüstle (15048801) Matthias Simon (15048804) Martin Glas (15048807) Björn Scheffler (15048810)
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
author_facet	Sied Kebir (15048732) Vivien Ullrich (15048735) Pia Berger (15048738) Celia Dobersalske (15048741) Sarah Langer (15048744) Laurèl Rauschenbach (15048747) Daniel Trageser (15048750) Andreas Till (15048753) Franziska K. Lorbeer (15048756) Anja Wieland (15048759) Timo Wilhelm-Buchstab (15048762) Ashar Ahmad (15048765) Holger Fröhlich (8724576) Igor Cima (15048768) Shruthi Prasad (15048771) Johann Matschke (15048774) Verena Jendrossek (15048777) Marc Remke (14962619) Barbara M. Grüner (14947089) Alexander Roesch (15048780) Jens T. Siveke (11780911) Christel Herold-Mende (15047946) Tobias Blau (15048783) Kathy Keyvani (15048786) Frank K.H. van Landeghem (15048789) Torsten Pietsch (15048792) Jörg Felsberg (15048795) Guido Reifenberger (12335398) Michael Weller (15037908) Ulrich Sure (15048798) Oliver Brüstle (15048801) Matthias Simon (15048804) Martin Glas (15048807) Björn Scheffler (15048810)
author_role	author
dc.creator.none.fl_str_mv	Sied Kebir (15048732) Vivien Ullrich (15048735) Pia Berger (15048738) Celia Dobersalske (15048741) Sarah Langer (15048744) Laurèl Rauschenbach (15048747) Daniel Trageser (15048750) Andreas Till (15048753) Franziska K. Lorbeer (15048756) Anja Wieland (15048759) Timo Wilhelm-Buchstab (15048762) Ashar Ahmad (15048765) Holger Fröhlich (8724576) Igor Cima (15048768) Shruthi Prasad (15048771) Johann Matschke (15048774) Verena Jendrossek (15048777) Marc Remke (14962619) Barbara M. Grüner (14947089) Alexander Roesch (15048780) Jens T. Siveke (11780911) Christel Herold-Mende (15047946) Tobias Blau (15048783) Kathy Keyvani (15048786) Frank K.H. van Landeghem (15048789) Torsten Pietsch (15048792) Jörg Felsberg (15048795) Guido Reifenberger (12335398) Michael Weller (15037908) Ulrich Sure (15048798) Oliver Brüstle (15048801) Matthias Simon (15048804) Martin Glas (15048807) Björn Scheffler (15048810)
dc.date.none.fl_str_mv	2025-11-25T12:46:40Z
dc.identifier.none.fl_str_mv	10.1158/1078-0432.30706287
dc.relation.none.fl_str_mv	https://figshare.com/articles/figure/Supplementary_Figure_S1_from_A_Sequential_Targeting_Strategy_Interrupts_AKT-Driven_Subclone-Mediated_Progression_in_Glioblastoma/30706287
dc.rights.none.fl_str_mv	CC BY info:eu-repo/semantics/openAccess
dc.subject.none.fl_str_mv	Cancer Therapeutic Research and Development Clinical Research and Trials CNS Cancers Gliomas, Glioblastomas Drug Targets Precision Medicine
dc.title.none.fl_str_mv	Supplementary Figure S1 from A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma
dc.type.none.fl_str_mv	Image Figure info:eu-repo/semantics/publishedVersion image
description	<p>Validation cohort, patient flow diagram. Patient enrollment and final inclusion of FFPE tissue samples in this study is shown. n = 3 patients were excluded from enrollment for reasons listed. The validation cohort comprised paired tissue samples from a total of n = 38 patients. Detailed characteristics in Supplementary Table S4. Note, the separate discovery cohort of paired vital cells is detailed in Supplementary Table S1. The GLASS cohort was used as an additional, external reference comprising data on n=37 patients extracted from (10).</p>
eu_rights_str_mv	openAccess
id	Manara_42b1d8d71d3a7b6caebe1d641db56a9c
identifier_str_mv	10.1158/1078-0432.30706287
network_acronym_str	Manara
network_name_str	ManaraRepo
oai_identifier_str	oai:figshare.com:article/30706287
publishDate	2025
repository.mail.fl_str_mv
repository.name.fl_str_mv
repository_id_str
rights_invalid_str_mv	CC BY
spelling	Supplementary Figure S1 from A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in GlioblastomaSied Kebir (15048732)Vivien Ullrich (15048735)Pia Berger (15048738)Celia Dobersalske (15048741)Sarah Langer (15048744)Laurèl Rauschenbach (15048747)Daniel Trageser (15048750)Andreas Till (15048753)Franziska K. Lorbeer (15048756)Anja Wieland (15048759)Timo Wilhelm-Buchstab (15048762)Ashar Ahmad (15048765)Holger Fröhlich (8724576)Igor Cima (15048768)Shruthi Prasad (15048771)Johann Matschke (15048774)Verena Jendrossek (15048777)Marc Remke (14962619)Barbara M. Grüner (14947089)Alexander Roesch (15048780)Jens T. Siveke (11780911)Christel Herold-Mende (15047946)Tobias Blau (15048783)Kathy Keyvani (15048786)Frank K.H. van Landeghem (15048789)Torsten Pietsch (15048792)Jörg Felsberg (15048795)Guido Reifenberger (12335398)Michael Weller (15037908)Ulrich Sure (15048798)Oliver Brüstle (15048801)Matthias Simon (15048804)Martin Glas (15048807)Björn Scheffler (15048810)CancerTherapeutic Research and DevelopmentClinical Research and TrialsCNS CancersGliomas, GlioblastomasDrug TargetsPrecision Medicine<p>Validation cohort, patient flow diagram. Patient enrollment and final inclusion of FFPE tissue samples in this study is shown. n = 3 patients were excluded from enrollment for reasons listed. The validation cohort comprised paired tissue samples from a total of n = 38 patients. Detailed characteristics in Supplementary Table S4. Note, the separate discovery cohort of paired vital cells is detailed in Supplementary Table S1. The GLASS cohort was used as an additional, external reference comprising data on n=37 patients extracted from (10).</p>2025-11-25T12:46:40ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1158/1078-0432.30706287https://figshare.com/articles/figure/Supplementary_Figure_S1_from_A_Sequential_Targeting_Strategy_Interrupts_AKT-Driven_Subclone-Mediated_Progression_in_Glioblastoma/30706287CC BYinfo:eu-repo/semantics/openAccessoai:figshare.com:article/307062872025-11-25T12:46:40Z
spellingShingle	Supplementary Figure S1 from A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma Sied Kebir (15048732) Cancer Therapeutic Research and Development Clinical Research and Trials CNS Cancers Gliomas, Glioblastomas Drug Targets Precision Medicine
status_str	publishedVersion
title	Supplementary Figure S1 from A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma
title_full	Supplementary Figure S1 from A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma
title_fullStr	Supplementary Figure S1 from A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma
title_full_unstemmed	Supplementary Figure S1 from A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma
title_short	Supplementary Figure S1 from A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma
title_sort	Supplementary Figure S1 from A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma
topic	Cancer Therapeutic Research and Development Clinical Research and Trials CNS Cancers Gliomas, Glioblastomas Drug Targets Precision Medicine

Supplementary Figure S1 from A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma

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