Short periods of increased connectivity between ROIs are characterized by a sparse overall network state.
<p><b>A</b>. Plots display binarized connectivity graphs for a single participant between 2.6 and 6.6 Hz during retrieval. Blue dots indicate recording channels. Light blue surfaces indicate the location of the hippocampi for anatomical reference. Black stippling indicates the cort...
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2025
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| author | Adam J. O. Dede (11554007) |
| author2 | Zachariah R. Cross (12517201) Samantha M. Gray (15280322) Joseph P. Kelly (22683512) Qin Yin (688027) Parisa Vahidi (6252611) Eishi Asano (10954801) Stephan U. Schuele (8892719) Joshua M. Rosenow (8892722) Joyce Y. Wu (3162564) Sandi K. Lam (10529066) Jeffrey S. Raskin (22683515) Jack J. Lin (7553783) Olivia Kim McManus (22683518) Shifteh Sattar (13215409) Ammar Shaikhouni (5722517) David King-Stephens (22683521) Peter B. Weber (22683524) Kenneth D. Laxer (14948857) Peter Brunner (290008) Jarod L. Roland (9193178) Ignacio Saez (2165584) Fady Girgis (17749833) Robert T. Knight (7108925) Noa Ofen (4059280) Elizabeth L. Johnson (12688232) |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author author |
| author_facet | Adam J. O. Dede (11554007) Zachariah R. Cross (12517201) Samantha M. Gray (15280322) Joseph P. Kelly (22683512) Qin Yin (688027) Parisa Vahidi (6252611) Eishi Asano (10954801) Stephan U. Schuele (8892719) Joshua M. Rosenow (8892722) Joyce Y. Wu (3162564) Sandi K. Lam (10529066) Jeffrey S. Raskin (22683515) Jack J. Lin (7553783) Olivia Kim McManus (22683518) Shifteh Sattar (13215409) Ammar Shaikhouni (5722517) David King-Stephens (22683521) Peter B. Weber (22683524) Kenneth D. Laxer (14948857) Peter Brunner (290008) Jarod L. Roland (9193178) Ignacio Saez (2165584) Fady Girgis (17749833) Robert T. Knight (7108925) Noa Ofen (4059280) Elizabeth L. Johnson (12688232) |
| author_role | author |
| dc.creator.none.fl_str_mv | Adam J. O. Dede (11554007) Zachariah R. Cross (12517201) Samantha M. Gray (15280322) Joseph P. Kelly (22683512) Qin Yin (688027) Parisa Vahidi (6252611) Eishi Asano (10954801) Stephan U. Schuele (8892719) Joshua M. Rosenow (8892722) Joyce Y. Wu (3162564) Sandi K. Lam (10529066) Jeffrey S. Raskin (22683515) Jack J. Lin (7553783) Olivia Kim McManus (22683518) Shifteh Sattar (13215409) Ammar Shaikhouni (5722517) David King-Stephens (22683521) Peter B. Weber (22683524) Kenneth D. Laxer (14948857) Peter Brunner (290008) Jarod L. Roland (9193178) Ignacio Saez (2165584) Fady Girgis (17749833) Robert T. Knight (7108925) Noa Ofen (4059280) Elizabeth L. Johnson (12688232) |
| dc.date.none.fl_str_mv | 2025-11-25T18:34:38Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pbio.3003481.g005 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Short_periods_of_increased_connectivity_between_ROIs_are_characterized_by_a_sparse_overall_network_state_/30714401 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Cell Biology Neuroscience Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified using intracranial eeg recognition memory task graph theoretic analysis sparse network states direct stimulus processing sparse connectivity aligned external stimulus presentation internal pfc peaks internal hfb peaks mtl theta connectivity stimulus presentation local processing generated states external event theta oscillations pfc changed patients performing global organization frequency broadband contrasting analyses anchored either analyses triggered |
| dc.title.none.fl_str_mv | Short periods of increased connectivity between ROIs are characterized by a sparse overall network state. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p><b>A</b>. Plots display binarized connectivity graphs for a single participant between 2.6 and 6.6 Hz during retrieval. Blue dots indicate recording channels. Light blue surfaces indicate the location of the hippocampi for anatomical reference. Black stippling indicates the cortical surface. Black lines represent connections with suprathreshold connectivity strength (pairwise phase consistency). i and ii display connections averaged across the time window between −425 and −75 ms relative to the Hip HFB peak. The red line indicates a connection between the ACC and Hip, which was elevated during successful retrieval for all participants (<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3003481#pbio.3003481.s010" target="_blank">S10A Fig</a>). Panel i displays connections during hit trials. ii. displays connections during miss trials. The binarization threshold was .1. This yielded 374 suprathreshold connections during hit trials and 1,622 during miss trials. iii and iv display similar connection graphs with connectivity values averaged across the time window between 0 and 1,500 ms relative to image onset. The binarization threshold was adjusted to .0686, which yielded 374 suprathreshold connections during hit trials—the same number as observed in the short time window analysis. However, unlike the short-time window analysis, there was not a marked increase in suprathreshold connections during miss trials. Specifically, there were 440 suprathreshold connections during miss trials. This panel can be regenerated using data contained in hip_acc_ret_HFB_2_21.mat and code in Figure5A_supFigure10B.m [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3003481#pbio.3003481.ref112" target="_blank">112</a>]. <b>B.</b> Graph theoretic measures taken for all connectivity graphs calculated using the time-frequency parameters of significant hit v. miss clusters. Characteristic path length and unweighted node strength both indicated more connected graphs during miss trials than hit trials, extending the effects seen in A across all participants and all connections. Each point represents one combination of participant, analysis timing (HFB-locked vs. image-locked), time, frequency, region 1, and region 2. Plots displaying these data separated by region and analysis timing are presented in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3003481#pbio.3003481.s010" target="_blank">S10 Fig</a>. This panel can be regenerated using data contained in graphDat.csv and code in graphMeasures.Rmd lines 336–432 [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3003481#pbio.3003481.ref112" target="_blank">112</a>].</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_4374619ebe425b6a5e8c837440f815d1 |
| identifier_str_mv | 10.1371/journal.pbio.3003481.g005 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30714401 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Short periods of increased connectivity between ROIs are characterized by a sparse overall network state.Adam J. O. Dede (11554007)Zachariah R. Cross (12517201)Samantha M. Gray (15280322)Joseph P. Kelly (22683512)Qin Yin (688027)Parisa Vahidi (6252611)Eishi Asano (10954801)Stephan U. Schuele (8892719)Joshua M. Rosenow (8892722)Joyce Y. Wu (3162564)Sandi K. Lam (10529066)Jeffrey S. Raskin (22683515)Jack J. Lin (7553783)Olivia Kim McManus (22683518)Shifteh Sattar (13215409)Ammar Shaikhouni (5722517)David King-Stephens (22683521)Peter B. Weber (22683524)Kenneth D. Laxer (14948857)Peter Brunner (290008)Jarod L. Roland (9193178)Ignacio Saez (2165584)Fady Girgis (17749833)Robert T. Knight (7108925)Noa Ofen (4059280)Elizabeth L. Johnson (12688232)Cell BiologyNeuroscienceEnvironmental Sciences not elsewhere classifiedBiological Sciences not elsewhere classifiedusing intracranial eegrecognition memory taskgraph theoretic analysissparse network statesdirect stimulus processingsparse connectivity alignedexternal stimulus presentationinternal pfc peaksinternal hfb peaksmtl theta connectivitystimulus presentationlocal processinggenerated statesexternal eventtheta oscillationspfc changedpatients performingglobal organizationfrequency broadbandcontrasting analysesanchored eitheranalyses triggered<p><b>A</b>. Plots display binarized connectivity graphs for a single participant between 2.6 and 6.6 Hz during retrieval. Blue dots indicate recording channels. Light blue surfaces indicate the location of the hippocampi for anatomical reference. Black stippling indicates the cortical surface. Black lines represent connections with suprathreshold connectivity strength (pairwise phase consistency). i and ii display connections averaged across the time window between −425 and −75 ms relative to the Hip HFB peak. The red line indicates a connection between the ACC and Hip, which was elevated during successful retrieval for all participants (<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3003481#pbio.3003481.s010" target="_blank">S10A Fig</a>). Panel i displays connections during hit trials. ii. displays connections during miss trials. The binarization threshold was .1. This yielded 374 suprathreshold connections during hit trials and 1,622 during miss trials. iii and iv display similar connection graphs with connectivity values averaged across the time window between 0 and 1,500 ms relative to image onset. The binarization threshold was adjusted to .0686, which yielded 374 suprathreshold connections during hit trials—the same number as observed in the short time window analysis. However, unlike the short-time window analysis, there was not a marked increase in suprathreshold connections during miss trials. Specifically, there were 440 suprathreshold connections during miss trials. This panel can be regenerated using data contained in hip_acc_ret_HFB_2_21.mat and code in Figure5A_supFigure10B.m [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3003481#pbio.3003481.ref112" target="_blank">112</a>]. <b>B.</b> Graph theoretic measures taken for all connectivity graphs calculated using the time-frequency parameters of significant hit v. miss clusters. Characteristic path length and unweighted node strength both indicated more connected graphs during miss trials than hit trials, extending the effects seen in A across all participants and all connections. Each point represents one combination of participant, analysis timing (HFB-locked vs. image-locked), time, frequency, region 1, and region 2. Plots displaying these data separated by region and analysis timing are presented in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3003481#pbio.3003481.s010" target="_blank">S10 Fig</a>. This panel can be regenerated using data contained in graphDat.csv and code in graphMeasures.Rmd lines 336–432 [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3003481#pbio.3003481.ref112" target="_blank">112</a>].</p>2025-11-25T18:34:38ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pbio.3003481.g005https://figshare.com/articles/figure/Short_periods_of_increased_connectivity_between_ROIs_are_characterized_by_a_sparse_overall_network_state_/30714401CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/307144012025-11-25T18:34:38Z |
| spellingShingle | Short periods of increased connectivity between ROIs are characterized by a sparse overall network state. Adam J. O. Dede (11554007) Cell Biology Neuroscience Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified using intracranial eeg recognition memory task graph theoretic analysis sparse network states direct stimulus processing sparse connectivity aligned external stimulus presentation internal pfc peaks internal hfb peaks mtl theta connectivity stimulus presentation local processing generated states external event theta oscillations pfc changed patients performing global organization frequency broadband contrasting analyses anchored either analyses triggered |
| status_str | publishedVersion |
| title | Short periods of increased connectivity between ROIs are characterized by a sparse overall network state. |
| title_full | Short periods of increased connectivity between ROIs are characterized by a sparse overall network state. |
| title_fullStr | Short periods of increased connectivity between ROIs are characterized by a sparse overall network state. |
| title_full_unstemmed | Short periods of increased connectivity between ROIs are characterized by a sparse overall network state. |
| title_short | Short periods of increased connectivity between ROIs are characterized by a sparse overall network state. |
| title_sort | Short periods of increased connectivity between ROIs are characterized by a sparse overall network state. |
| topic | Cell Biology Neuroscience Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified using intracranial eeg recognition memory task graph theoretic analysis sparse network states direct stimulus processing sparse connectivity aligned external stimulus presentation internal pfc peaks internal hfb peaks mtl theta connectivity stimulus presentation local processing generated states external event theta oscillations pfc changed patients performing global organization frequency broadband contrasting analyses anchored either analyses triggered |