Figure 6 from Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases
<p>Topographic immune cell deconvolution primary colorectal cancer and CRLM. <b>A,</b> Images (from <a href="#fig4" target="_blank">Fig. 4A</a>) of primary colorectal cancer (bottom) and CRLM (top) with 48 ROIs superimposed. Abundance estimates as de...
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| _version_ | 1849927638742728704 |
|---|---|
| author | Colin S. Wood (15293247) |
| author2 | Kathryn A.F. Pennel (15293250) Holly Leslie (15293253) Assya Legrini (15293256) Andrew J. Cameron (15046037) Lydia Melissourgou-Syka (15293259) Jean A. Quinn (15293262) Hester C. van Wyk (15293265) Jennifer Hay (15293268) Antonia K. Roseweir (15293271) Colin Nixon (14949516) Campbell S.D. Roxburgh (15293274) Donald C. McMillan (15293277) Andrew V. Biankin (14937726) Owen J. Sansom (14949234) Paul G. Horgan (15293280) Joanne Edwards (14939606) Colin W. Steele (15293283) Nigel B. Jamieson (15046064) |
| author2_role | author author author author author author author author author author author author author author author author author author |
| author_facet | Colin S. Wood (15293247) Kathryn A.F. Pennel (15293250) Holly Leslie (15293253) Assya Legrini (15293256) Andrew J. Cameron (15046037) Lydia Melissourgou-Syka (15293259) Jean A. Quinn (15293262) Hester C. van Wyk (15293265) Jennifer Hay (15293268) Antonia K. Roseweir (15293271) Colin Nixon (14949516) Campbell S.D. Roxburgh (15293274) Donald C. McMillan (15293277) Andrew V. Biankin (14937726) Owen J. Sansom (14949234) Paul G. Horgan (15293280) Joanne Edwards (14939606) Colin W. Steele (15293283) Nigel B. Jamieson (15046064) |
| author_role | author |
| dc.creator.none.fl_str_mv | Colin S. Wood (15293247) Kathryn A.F. Pennel (15293250) Holly Leslie (15293253) Assya Legrini (15293256) Andrew J. Cameron (15046037) Lydia Melissourgou-Syka (15293259) Jean A. Quinn (15293262) Hester C. van Wyk (15293265) Jennifer Hay (15293268) Antonia K. Roseweir (15293271) Colin Nixon (14949516) Campbell S.D. Roxburgh (15293274) Donald C. McMillan (15293277) Andrew V. Biankin (14937726) Owen J. Sansom (14949234) Paul G. Horgan (15293280) Joanne Edwards (14939606) Colin W. Steele (15293283) Nigel B. Jamieson (15046064) |
| dc.date.none.fl_str_mv | 2025-11-24T23:04:50Z |
| dc.identifier.none.fl_str_mv | 10.1158/0008-5472.30700327 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Figure_6_from_Spatially_Resolved_Transcriptomics_Deconvolutes_Prognostic_Histological_Subgroups_in_Patients_with_Colorectal_Cancer_and_Synchronous_Liver_Metastases/30700327 |
| dc.rights.none.fl_str_mv | CC BY info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Cancer Tumor Biology Cancer Detection and Diagnosis Methods and Technology Biomarkers Diagnostic biomarkers Gastrointestinal Cancers Colorectal cancer Gene Technologies High-throughput sequencing Progression, Invasion & Metastasis |
| dc.title.none.fl_str_mv | Figure 6 from Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>Topographic immune cell deconvolution primary colorectal cancer and CRLM. <b>A,</b> Images (from <a href="#fig4" target="_blank">Fig. 4A</a>) of primary colorectal cancer (bottom) and CRLM (top) with 48 ROIs superimposed. Abundance estimates as determined from transcriptome by SpatialDecon for 14 cell populations illustrated for each ROI with color coding detailing the annotated tumor region. Radius is proportional to the estimated cell counts within the ROI. The immune cell count per region was extracted and the square root of the ratio to the mean immune cell count per region (41.37) of all immune cells was calculated and is displayed. The square root of the ratio was calculated to minimize the skew caused by variance of highly expressed cell types. <b>B,</b> Box plots demonstrating the median and interquartile range for each cell type analyzed organized by cell type and topographic region and grouped by KM grade. All ROIs taken from primary colorectal cancer except TLR are grouped as primary. Dendritic cells were removed due to insignificant counts. The Mann–Whitney test was used to assess for statistical significance; *, <i>P</i> < 0.05.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_4441ffafd5d2a3b503e89bf13bc0d10a |
| identifier_str_mv | 10.1158/0008-5472.30700327 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30700327 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY |
| spelling | Figure 6 from Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver MetastasesColin S. Wood (15293247)Kathryn A.F. Pennel (15293250)Holly Leslie (15293253)Assya Legrini (15293256)Andrew J. Cameron (15046037)Lydia Melissourgou-Syka (15293259)Jean A. Quinn (15293262)Hester C. van Wyk (15293265)Jennifer Hay (15293268)Antonia K. Roseweir (15293271)Colin Nixon (14949516)Campbell S.D. Roxburgh (15293274)Donald C. McMillan (15293277)Andrew V. Biankin (14937726)Owen J. Sansom (14949234)Paul G. Horgan (15293280)Joanne Edwards (14939606)Colin W. Steele (15293283)Nigel B. Jamieson (15046064)CancerTumor BiologyCancer Detection and DiagnosisMethods and TechnologyBiomarkersDiagnostic biomarkersGastrointestinal CancersColorectal cancerGene TechnologiesHigh-throughput sequencingProgression, Invasion & Metastasis<p>Topographic immune cell deconvolution primary colorectal cancer and CRLM. <b>A,</b> Images (from <a href="#fig4" target="_blank">Fig. 4A</a>) of primary colorectal cancer (bottom) and CRLM (top) with 48 ROIs superimposed. Abundance estimates as determined from transcriptome by SpatialDecon for 14 cell populations illustrated for each ROI with color coding detailing the annotated tumor region. Radius is proportional to the estimated cell counts within the ROI. The immune cell count per region was extracted and the square root of the ratio to the mean immune cell count per region (41.37) of all immune cells was calculated and is displayed. The square root of the ratio was calculated to minimize the skew caused by variance of highly expressed cell types. <b>B,</b> Box plots demonstrating the median and interquartile range for each cell type analyzed organized by cell type and topographic region and grouped by KM grade. All ROIs taken from primary colorectal cancer except TLR are grouped as primary. Dendritic cells were removed due to insignificant counts. The Mann–Whitney test was used to assess for statistical significance; *, <i>P</i> < 0.05.</p>2025-11-24T23:04:50ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1158/0008-5472.30700327https://figshare.com/articles/figure/Figure_6_from_Spatially_Resolved_Transcriptomics_Deconvolutes_Prognostic_Histological_Subgroups_in_Patients_with_Colorectal_Cancer_and_Synchronous_Liver_Metastases/30700327CC BYinfo:eu-repo/semantics/openAccessoai:figshare.com:article/307003272025-11-24T23:04:50Z |
| spellingShingle | Figure 6 from Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases Colin S. Wood (15293247) Cancer Tumor Biology Cancer Detection and Diagnosis Methods and Technology Biomarkers Diagnostic biomarkers Gastrointestinal Cancers Colorectal cancer Gene Technologies High-throughput sequencing Progression, Invasion & Metastasis |
| status_str | publishedVersion |
| title | Figure 6 from Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases |
| title_full | Figure 6 from Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases |
| title_fullStr | Figure 6 from Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases |
| title_full_unstemmed | Figure 6 from Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases |
| title_short | Figure 6 from Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases |
| title_sort | Figure 6 from Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases |
| topic | Cancer Tumor Biology Cancer Detection and Diagnosis Methods and Technology Biomarkers Diagnostic biomarkers Gastrointestinal Cancers Colorectal cancer Gene Technologies High-throughput sequencing Progression, Invasion & Metastasis |