Circoplots of two representative loci.

Circoplots of two representative loci.

<p>Region plots for two novel pain risk loci as representative of those associated with multiple pain traits (A) vs. those with greater trait specificity (B). A. Locus associated with both Headache/Migraine and Muscular pain centered on chromosome 3q26.31 at the UTR5 of <i>NLGN1</i>...

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Bibliographic Details
Main Author: Evelina Mocci (374296) (author)
Other Authors: Kathryn Ward (17174753) (author), James A. Perry (10515389) (author), Angela Starkweather (10581244) (author), Laura S. Stone (9392671) (author), Siobhan M. Schabrun (11929656) (author), Cynthia Renn (17174756) (author), Susan G. Dorsey (11780093) (author), Seth A. Ament (9427801) (author)
Published: 2023
Subjects:
Cell Biology
Genetics
Physiology
Ecology
Immunology
Biological Sciences not elsewhere classified
public health system
growing opioid crisis
immunological traits mediate
genetic relationship among
remaining 34 loci
overlap loci identified
wide association studies
chronic pain compared
loci primarily associated
loci associated
related traits
genetic correlation
risk loci
loci fall
99 loci
united states
uk biobank
specific pain
skeletomuscular pain
significant burden
related pain
pleiotropic relationships
pain susceptibility
multiple forms
joint analysis
inflammatory pathways
healthy controls
genomic proximity
genes involved
four categories
epidemic proportions
earlier studies
chromatin interaction
applied leave
664 genes
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