Data Sheet 1_Risk factors of osteonecrosis in patients with systemic lupus erythematosus: a meta-analysis.docx
Background<p>This study aimed to explore risk factors for osteonecrosis in patients with systemic lupus erythematosus by meta-analysis.</p>Methods<p>PubMed, Embase, Web of Science, and Cochrane Library were searched for case–control/cohort studies on the occurrence of osteonecrosis...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | |
| منشور في: |
2025
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| الملخص: | Background<p>This study aimed to explore risk factors for osteonecrosis in patients with systemic lupus erythematosus by meta-analysis.</p>Methods<p>PubMed, Embase, Web of Science, and Cochrane Library were searched for case–control/cohort studies on the occurrence of osteonecrosis in patients with systemic lupus erythematosus from the time the database was created until 1 December 2024. Data were analyzed using Stata 15.0, and the quality of the included studies was evaluated using the NOS score.</p>Result<p>A total of 14 articles, including 3,890 patients, were included in the study, and the meta-analysis indicates that younger age in SLE patients [SMD = −0.23, 95% CI (−0.39, −0.06)], diabetes mellitus [OR = 1.78, 95% CI (1.03, 3.09)], hypertension [OR = 1.33, 95% CI (1.03, 1.72)], arthritis [OR = 1.57, 95% CI (1.24, 2.00)], Raynaud’s phenomenon [OR = 1.76, 95% CI (1.35, 2.30)], and cyclophosphamide use [OR = 2.24, 95% CI (1.38, 3.63)] are risk factors for the development of osteonecrosis in patients with SLE.</p>Conclusion<p>The current study found that younger age, hypertension, diabetes, arthritis, Raynaud’s phenomenon, and cyclophosphamide use are independent risk factors for the development of osteonecrosis in patients with SLE.</p> |
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