Self-Surfactant Poly-3hydroxybutyrate-<i>co</i>-3hydroxyhexanoate (PHBHHx) for the Preparation of Usnic Acid Loaded Antimicrobial Nanoparticles Using Nontoxic Chemicals

Self-Surfactant Poly-3hydroxybutyrate-<i>co</i>-3hydroxyhexanoate (PHBHHx) for the Preparation of Usnic Acid Loaded Antimicrobial Nanoparticles Using Nontoxic Chemicals

Polyhydroxyalkanoates (PHAs) are naturally occurring polyesters with promising drug delivery applications. Their hydrophobicity enables lipophilic drug encapsulation, enhancing bioavailability but limiting colloidal stability and physiological compatibility. Surfactants crucially improve the nanopar...

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Bibliographische Detailangaben
1. Verfasser: Sara Alfano (17253471) (author)
Weitere Verfasser: Lorenzo Ceparano (21573027) (author), Benedetta Brugnoli (17973200) (author), Gianluca Forcina (18575499) (author), Luca Pellegrino (2440054) (author), Francesca Cecilia Lauta (21573030) (author), Roberto Rusconi (443597) (author), Iolanda Francolini (1955998) (author), Antonella Piozzi (1955995) (author), Andrea Martinelli (1955980) (author)
Veröffentlicht: 2025
Schlagworte:
Biochemistry
Medicine
Pharmacology
Biotechnology
Ecology
Space Science
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
systemic drug delivery
surfactants crucially improve
stable colloidal suspensions
solvent evaporation method
smart implant coatings
naturally occurring polyesters
nanoparticle dimensional stability
limiting colloidal stability
green chemical modification
free usnic acid
fluidic conditions even
biological evaluations demonstrated
biocompatible ionic liquid
aureus newman strain
antibacterial topical formulations
retaining antimicrobial activity
high cytotoxicity observed
surfactant systems offer
surfactant systems
antimicrobial efficacy
toxic reagents
scalable strategy
research proposes
precisely controlling
physiological compatibility
molar ratio
introduced onto
infrared spectroscopy
hydroxybutyrate -<
hydrophobic matrices
hydrophilic groups
enhancing bioavailability
concentrations ranging
complex purification
co </
chromatographic analysis
cellular interaction
biofilm inhibition
approach offers
approach eliminates
amphiphilic structures
>- 3hydroxyhexanoate
3hydroxybutyrate -<
1 μg
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