Self-Surfactant Poly-3hydroxybutyrate-<i>co</i>-3hydroxyhexanoate (PHBHHx) for the Preparation of Usnic Acid Loaded Antimicrobial Nanoparticles Using Nontoxic Chemicals

Polyhydroxyalkanoates (PHAs) are naturally occurring polyesters with promising drug delivery applications. Their hydrophobicity enables lipophilic drug encapsulation, enhancing bioavailability but limiting colloidal stability and physiological compatibility. Surfactants crucially improve the nanopar...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Sara Alfano (17253471) (author)
مؤلفون آخرون:	Lorenzo Ceparano (21573027) (author), Benedetta Brugnoli (17973200) (author), Gianluca Forcina (18575499) (author), Luca Pellegrino (2440054) (author), Francesca Cecilia Lauta (21573030) (author), Roberto Rusconi (443597) (author), Iolanda Francolini (1955998) (author), Antonella Piozzi (1955995) (author), Andrea Martinelli (1955980) (author)
منشور في:	2025
الموضوعات:	Biochemistry Medicine Pharmacology Biotechnology Ecology Space Science Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified systemic drug delivery surfactants crucially improve stable colloidal suspensions solvent evaporation method smart implant coatings naturally occurring polyesters nanoparticle dimensional stability limiting colloidal stability green chemical modification free usnic acid fluidic conditions even biological evaluations demonstrated biocompatible ionic liquid aureus newman strain antibacterial topical formulations retaining antimicrobial activity high cytotoxicity observed surfactant systems offer surfactant systems antimicrobial efficacy toxic reagents scalable strategy research proposes precisely controlling physiological compatibility molar ratio introduced onto infrared spectroscopy hydroxybutyrate -< hydrophobic matrices hydrophilic groups enhancing bioavailability concentrations ranging complex purification co </ chromatographic analysis cellular interaction biofilm inhibition approach offers approach eliminates amphiphilic structures >- 3hydroxyhexanoate 3hydroxybutyrate -< 1 μg
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Self-Surfactant Poly-3hydroxybutyrate-<i>co</i>-3hydroxyhexanoate (PHBHHx) for the Preparation of Usnic Acid Loaded Antimicrobial Nanoparticles Using Nontoxic Chemicals

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