Vpr localization within cell compartments does not change following vorinostat treatment.

Vpr localization within cell compartments does not change following vorinostat treatment.

<p>Western blot with indicated antibody on cell fractions from cells treated with DMSO or vorinostat. VOR = vorinostat. Sol nuc = soluble nuclear fraction.</p> <p>(TIF)</p>

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Dettagli Bibliografici
Autore principale:	Catherine A. Lewis (22177707) (author)
Altri autori:	David M. Margolis (244046) (author), Edward P. Browne (8913893) (author)
Pubblicazione:	2025
Soggetti:	Cell Biology Molecular Biology Biotechnology Immunology Developmental Biology Cancer Infectious Diseases Virology vorinostat potently enhances viral factors shape viral factors interact sup >+</ sup specific viral factors div >< p critical cellular factors 1 reporter strains 1 accessory proteins 1 accessory protein reservoir formation selects preventing reservoir formation regulate latency establishment 1 latency results 1 latency establishment prevents hiv transmission cure hiv infection vpr &# 8217 latent viral reservoir 1 protein vpr whether hdacs interact cell latency model host cell factors promoting hiv expression central memory cd4 latent reservoir central memory 1 entry vpr expression new latency cell subtypes cell death latent proviruses single hiv individual hiv allow hiv vpr possesses vpr plays significant increase recently shown promoting activity primary cd4 mediated restriction induced apoptosis histone deacetylases findings suggest dramatically improved clinical prognosis binding domain antiretroviral therapy
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