Increasing true ROH length corresponds to increasing detection.

Increasing true ROH length corresponds to increasing detection.

<p>Called <i>F</i><sub>ROH</sub>−True <i>F</i><sub>ROH</sub> displayed by length bin (short, intermediate, long, very long) and demographic scenario (A: large population; B: small population; C: bottlenecked population; D: declining population) a...

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محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Gabriel A. A. Silva (19996766) (author)
مؤلفون آخرون:	Avril M. Harder (12372637) (author), Kenneth B. Kirksey (19996769) (author), Samarth Mathur (6690962) (author), Janna R. Willoughby (8027312) (author)
منشور في:	2024
الموضوعات:	Genetics Evolutionary Biology Ecology Science Policy Biological Sciences not elsewhere classified mediated climate change land use changes incorrectly lumped together genetic mechanisms contributing also shed light roh detection tools lower sequencing depths underestimating inbreeding signals term demographic history small true rohs roh length distribution individual inbreeding present demographic history roh length individual fitness also found sequencing effort sequencing depth roh inferences roh inference roh estimation recent inbreeding inbreeding increases inbreeding depression suggest using specific inferences sensitivity analysis programs used program selection populations decline popular strategy particularly pronounced particularly important parameter exploration negative effects multiple levels magnitude varying longer rohs increasingly threatened generate robust estimation biases erroneous inference endangered species empirical datasets either underestimation downstream effects dependent biases bias direction analyze simulated analysis parameters
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الملخص:	<p>Called <i>F</i><sub>ROH</sub>−True <i>F</i><sub>ROH</sub> displayed by length bin (short, intermediate, long, very long) and demographic scenario (A: large population; B: small population; C: bottlenecked population; D: declining population) at 15X (<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012566#sec012" target="_blank">results</a> for all coverage levels presented in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012566#pcbi.1012566.s015" target="_blank">S9</a>–<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012566#pcbi.1012566.s016" target="_blank">S10</a> Figs). For BCFtools Genotypes and PLINK, <i>F</i><sub>ROH</sub> for short ROHs is consistently underestimated whereas <i>F</i><sub>ROH</sub> for very long ROHs is overestimated when these ROHs are present. BCFtools Likelihoods does not overestimate ROHs in any length bin.</p>