Figure 5 from Translational Activation of ATF4 through Mitochondrial Anaplerotic Metabolic Pathways Is Required for DLBCL Growth and Survival

Figure 5 from Translational Activation of ATF4 through Mitochondrial Anaplerotic Metabolic Pathways Is Required for DLBCL Growth and Survival

<p>ATF4 protein level is regulated downstream of the SIRT3–GDH–TCA cycle–autophagy cascade. <b>A,</b> Western blots show the effects of ATF4 expression to autophagy activation induced by SIRT3 shRNA in Karpas 422 cells. Protein level changes were quantified with densitometry result...

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Bibliografske podrobnosti
Glavni avtor: Meng Li (79487) (author)
Drugi avtorji: Matthew R. Teater (15129060) (author), Jun Young Hong (6588914) (author), Noel R. Park (15129063) (author), Cihangir Duy (15112006) (author), Hao Shen (195461) (author), Ling Wang (56577) (author), Zhengming Chen (385056) (author), Leandro Cerchietti (15091552) (author), Shawn M. Davidson (14911596) (author), Hening Lin (1306563) (author), Ari M. Melnick (15110132) (author)
Izdano: 2025
Teme:
Cancer
Molecular and Cellular Biology
Cellular Stress Responses
Gene Regulation
Posttranscriptional and translational control
Hematological Cancers
Lymphomas
Metabolism
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