Comparison of the decrease of CFU in CSF and blood between treatment groups within the first 6 h after treatment.

(A) Comparison of CFU reduction in CSF and (B) in blood. Statistical significance was determined using Fisher’s exact test. Animals displaying bacterial loads below the limit of detection throughout the experiment or missing follow-up sampling were excl...

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Bibliographic Details
Main Author:	Luca G. Valente (12463057) (author)
Other Authors:	Ngoc Dung Le (9367537) (author), Melissa Pitton (12463060) (author), Gabriele Chiffi (5305379) (author), Denis Grandgirard (135504) (author), Stephan M. Jakob (8533476) (author), David R. Cameron (9767792) (author), Grégory Resch (387788) (author), Yok-Ai Que (70055) (author), Stephen L. Leib (6817163) (author)
Published:	2022
Subjects:	Biochemistry Medicine Microbiology Cell Biology Pharmacology Biotechnology Ecology Immunology Infectious Diseases Virology resistant clinical strain phosphate buffered saline pharmacokinetic studies indicated infant wistar rats infant rat model increasing clinical challenge galenic formulation e drug resistant strains controlled experimental study antibiotics warrant investigation >, serotype 19a within 25 h whereas vancomycin sterilized vancomycin treated animals resistant pneumococcal meningitis experimental pneumococcal meningitis attractive therapeutic candidates via intraperitoneal injection reduce bacterial loads pneumococcal meningitis due novel endolysin plyaz3a hpi ), animals current study assessed blood brain barrier 5 x 10 3 treatment groups serum 2 h pbs ], n improve survival compared 7 </ sup intraperitoneal injection bacterial loads kg vancomycin 12 h therapeutic potential 42 hpi infection due treatment failure significant improvement secondary outcomes received either primary outcome pneumoniae </ peak concentration kg plyaz3a cerebrospinal fluid antibiotic resistance </ sup 8 ), 785 μg 50 mg 400 mg
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Comparison of the decrease of CFU in CSF and blood between treatment groups within the first 6 h after treatment.

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